DNASE1L3

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.[5][6][7][8]

DNASE1L3
Identifiers
Aliases	DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16, deoxyribonuclease I like 3, deoxyribonuclease 1 like 3
External IDs	OMIM: 602244 MGI: 1314633 HomoloGene: 3630 GeneCards: DNASE1L3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 58,192,257 bp[1] End 58,214,697 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A1 Start 7,964,533 bp[2] End 7,994,573 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • calcium ion binding • nuclease activity • endonuclease activity • endodeoxyribonuclease activity • hydrolase activity • deoxyribonuclease activity • deoxyribonuclease I activity Cellular component • extracellular region • endoplasmic reticulum • cell nucleus Biological process • DNA metabolic process • DNA catabolic process • programmed cell death involved in cell development • apoptotic process • programmed cell death • apoptotic DNA fragmentation • DNA catabolic process, endonucleolytic • neutrophil activation involved in immune response • regulation of acute inflammatory response • regulation of neutrophil mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1776	13421
Ensembl	ENSG00000163687	ENSMUSG00000025279
UniProt	Q13609	O55070
RefSeq (mRNA)	NM_004944 NM_001256560	NM_007870
RefSeq (protein)	NP_001243489 NP_004935	NP_031896
Location (UCSC)	Chr 3: 58.19 – 58.21 Mb	Chr 14: 7.96 – 7.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[8]

Homozygosity for a null allele results in systemic lupus erythematosus.[9]. A loss of function allele in DNASE1L3 is associated with rheumatoid arthritis[10].

References

1. GRCh38: Ensembl release 89: ENSG00000163687 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025279 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (June 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
6. Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (July 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
7. Shiokawa D, Hirai M, Tanuma S (March 1998). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506.
8. "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".
9. Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, et al. (October 2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–8. doi:10.1038/ng.975. PMID 22019780.
10. Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, et al. (October 2018). "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes". Nature Genetics. 50 (10): 1366–1374. doi:10.1038/s41588-018-0216-7. PMC 6364548. PMID 30224649.

Further reading

• Tanuma S, Shiokawa D (September 1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochemical and Biophysical Research Communications. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058.
• Zeng Z, Parmelee D, Hyaw H, Coleman TA, Su K, Zhang J, et al. (February 1997). "Cloning and characterization of a novel human DNase". Biochemical and Biophysical Research Communications. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308.
• Shiokawa D, Tanuma S (January 2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.
• Wilber A, Lu M, Schneider MC (July 2002). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection". Molecular Therapy. 6 (1): 35–42. doi:10.1006/mthe.2002.0625. PMID 12095301.
• Boulares AH, Zoltoski AJ, Sherif ZA, Yakovlev AG, Smulson ME (August 2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells". Cancer Research. 62 (15): 4439–44. PMID 12154052.
• Shiokawa D, Shika Y, Tanuma S (December 2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity". The Biochemical Journal. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMC 1223774. PMID 12943533.
• Boulares AH, Ren T (January 2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3". Basic & Clinical Pharmacology & Toxicology. 94 (1): 19–29. doi:10.1111/j.1742-7843.2004.pto_940105.x. PMID 14725611.
• Okamoto M, Okamoto N, Yashiro H, Shiokawa D, Sunaga S, Yoshimori A, et al. (February 2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes". Biochemical and Biophysical Research Communications. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432.
• Boulares H, Zoltoski A, Kandan S, Akbulut T, Yakovlev A, Oumouna M (March 2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression". Biochemical and Biophysical Research Communications. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.