DNASE1L1

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene.[5][6][7]

DNASE1L1
Identifiers
Aliases	DNASE1L1, DNAS1L1, DNASEX, DNL1L, G4.8, XIB, deoxyribonuclease I-like 1, deoxyribonuclease 1 like 1
External IDs	OMIM: 300081 MGI: 109628 HomoloGene: 4896 GeneCards: DNASE1L1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,401,236 bp[1] End 154,412,112 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.94 cM Start 74,273,217 bp[2] End 74,282,337 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nuclease activity • endonuclease activity • hydrolase activity • deoxyribonuclease activity • deoxyribonuclease I activity Cellular component • endoplasmic reticulum • extracellular region • specific granule lumen • cell nucleus Biological process • DNA metabolic process • DNA catabolic process • nucleic acid phosphodiester bond hydrolysis • neutrophil degranulation • DNA catabolic process, endonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1774	69537
Ensembl	ENSG00000013563	ENSMUSG00000019088
UniProt	P49184	Q9D7J6
RefSeq (mRNA)	NM_001009932 NM_001009933 NM_001009934 NM_001303620 NM_006730	NM_001172154 NM_027109 NM_001370787
RefSeq (protein)	NP_001009932 NP_001009933 NP_001009934 NP_001290549 NP_006721	NP_001165625 NP_081385 NP_001357716
Location (UCSC)	Chr X: 154.4 – 154.41 Mb	Chr X: 74.27 – 74.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000013563 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019088 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL (Feb 1996). "A muscle-specific DNase I-like gene in human Xq28". Hum Mol Genet. 4 (9): 1557–64. doi:10.1093/hmg/4.9.1557. PMID 8541839.
6. Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I (Jul 1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region". Gene. 168 (2): 267–70. doi:10.1016/0378-1119(95)00741-5. PMID 8654957.
7. "Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1".

Further reading

• Chen EY, Zollo M, Mazzarella R, et al. (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum. Mol. Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
• Rodriguez AM, Rodin D, Nomura H, et al. (1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
• Malferrari G, Mazza U, Tresoldi C, et al. (1999). "Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders". Exp. Mol. Pathol. 66 (2): 123–30. doi:10.1006/exmp.1999.2254. PMID 10409440.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Shiokawa D, Shika Y, Saito K, et al. (2006). "Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X". Biochem. J. 392 (Pt 3): 511–7. doi:10.1042/BJ20051114. PMC 1316290. PMID 16107205.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Coy JF, Velhagen I, Himmele R, et al. (1996). "Isolation, differential splicing and protein expression of a DNase on the human X chromosome". Cell Death Differ. 3 (2): 199–206. PMID 17180083.