DHRS4

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.[5][6][7]

DHRS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4R
Identifiers
Aliases	DHRS4, CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2, dehydrogenase/reductase (SDR family) member 4, dehydrogenase/reductase 4
External IDs	OMIM: 611596 MGI: 90169 HomoloGene: 49646 GeneCards: DHRS4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,953,734 bp[1] End 23,969,279 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,478,758 bp[2] End 55,490,340 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • alcohol dehydrogenase [NAD(P)+ activity] • receptor binding • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • carbonyl reductase (NADPH) activity • 3-keto sterol reductase activity • NADP-retinol dehydrogenase activity Cellular component • peroxisomal membrane • peroxisome • extracellular exosome • endoplasmic reticulum membrane • mitochondrion • cell nucleus • peroxisomal matrix • cytosol Biological process • steroid metabolic process • alcohol metabolic process • oxidation-reduction process • protein tetramerization • cellular ketone metabolic process • retinol metabolic process • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10901	28200
Ensembl	ENSG00000157326 ENSG00000284807	ENSMUSG00000022210
UniProt	Q9BTZ2	Q99LB2
RefSeq (mRNA)	NM_001282987 NM_001282988 NM_001282989 NM_001282990 NM_001282991 NM_021004	NM_001037938 NM_030686
RefSeq (protein)	NP_001269916 NP_001269917 NP_001269918 NP_001269919 NP_001269920 NP_066284	NP_001033027 NP_109611
Location (UCSC)	Chr 14: 23.95 – 23.97 Mb	Chr 14: 55.48 – 55.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000284807 GRCh38: Ensembl release 89: ENSG00000157326, ENSG00000284807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022210 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. PMC 1220285. PMID 10333503.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
7. "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

Further reading

• Song XH, Liang B, Liu GF, et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer. 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Du J, Huang DY, Liu GF, et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao. 31 (7): 661–7. PMID 15473316.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.