DENND4A

C-myc promoter-binding protein is a protein that in humans is encoded by the DENND4A gene.[5][6][7]

DENND4A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PSN, 3B97
Identifiers
Aliases	DENND4A, IRLB, MYCPBP, DENN domain containing 4A
External IDs	OMIM: 600382 MGI: 2142979 HomoloGene: 55933 GeneCards: DENND4A
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,658,046 bp[1] End 65,792,293 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,811,340 bp[2] End 64,919,667 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • guanyl-nucleotide exchange factor activity • Rab guanyl-nucleotide exchange factor activity • GO:0001948 protein binding Cellular component • cell nucleus • cytosol Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10260	102442
Ensembl	ENSG00000174485	ENSMUSG00000053641
UniProt	Q7Z401	n/a
RefSeq (mRNA)	NM_001144823 NM_005848 NM_001320835 NM_001376919 NM_001376920	NM_001162917 NM_176935
RefSeq (protein)	NP_001138295 NP_001307764 NP_005839 NP_001363848 NP_001363849	n/a
Location (UCSC)	Chr 15: 65.66 – 65.79 Mb	Chr 9: 64.81 – 64.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000174485 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053641 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stasiv YZ, Mashkova TD, Chernov BK, Sokolova IV, Itkes AV, Kisselev LL (Sep 1994). "Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element". Gene. 145 (2): 267–72. doi:10.1016/0378-1119(94)90018-3. PMID 8056341.
6. Semova N, Kapanadze B, Corcoran M, Kutsenko A, Baranova A, Semov A (Aug 2003). "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges small star, filled". Genomics. 82 (3): 343–54. doi:10.1016/S0888-7543(03)00103-4. PMID 12906859.
7. "Entrez Gene: DENND4A DENN/MADD domain containing 4A".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Uramoto H, Izumi H, Ise T, et al. (2002). "p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression". J. Biol. Chem. 277 (35): 31694–702. doi:10.1074/jbc.M200266200. PMID 12080043.

External links

• DENND4A human gene location in the UCSC Genome Browser.
• DENND4A human gene details in the UCSC Genome Browser.