DEFB105A

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.[5][6][7]

DEFB105A
Identifiers
Aliases	DEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDs	MGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 7,821,966 bp[1] End 7,823,889 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.3 Start 19,111,931 bp[2] End 19,114,839 bp[2]
Orthologs
Species	Human	Mouse
Entrez	245908	77674
Ensembl	ENSG00000186562	ENSMUSG00000043787
UniProt	Q8NG35	Q8K4N3
RefSeq (mRNA)	NM_152250	NM_152802
RefSeq (protein)	NP_689463	NP_690015
Location (UCSC)	Chr 8: 7.82 – 7.82 Mb	Chr 8: 19.11 – 19.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000186562 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
6. Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
7. "Entrez Gene: DEFB105A defensin, beta 105A".

Further reading

• Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865.
• Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
• Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence". BMC Genomics. 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC 544879. PMID 15588320.
• Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683. PMID 12916016.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.