DEFB105A

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.[5][6][7]

DEFB105A
Identifiers
AliasesDEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDsMGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p23.1Start7,821,966 bp[1]
End7,823,889 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

245908

77674

Ensembl

ENSG00000186562

ENSMUSG00000043787

UniProt

Q8NG35

Q8K4N3

RefSeq (mRNA)

NM_152250

NM_152802

RefSeq (protein)

NP_689463

NP_690015

Location (UCSC)Chr 8: 7.82 – 7.82 MbChr 8: 19.11 – 19.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000186562 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043787 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  6. Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
  7. "Entrez Gene: DEFB105A defensin, beta 105A".

Further reading

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