DDX43

Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene.[5][6]

DDX43
Identifiers
Aliases	DDX43, CT13, HAGE, DEAD-box helicase 43
External IDs	OMIM: 606286 MGI: 3642857 HomoloGene: 56814 GeneCards: DDX43
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q13 Start 73,394,828 bp[1] End 73,417,566 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E1 Start 78,395,777 bp[2] End 78,423,587 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATP binding • hydrolase activity • nucleotide binding • nucleic acid binding • GO:0008026 helicase activity • RNA binding Cellular component • intracellular • nucleolus • cytoplasm Biological process • RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55510	100048658
Ensembl	ENSG00000080007	ENSMUSG00000070291
UniProt	Q9NXZ2	D3Z6P9
RefSeq (mRNA)	NM_018665	NM_001191044
RefSeq (protein)	NP_061135	NP_001177973
Location (UCSC)	Chr 6: 73.39 – 73.42 Mb	Chr 9: 78.4 – 78.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD box family and displays tumor-specific expression.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080007 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070291 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martelange V, De Smet C, De Plaen E, Lurquin C, Boon T (Aug 2000). "Identification on a human sarcoma of two new genes with tumor-specific expression". Cancer Res. 60 (14): 3848–55. PMID 10919659.
6. "Entrez Gene: DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Nagel H, Laskawi R, Eiffert H, Schlott T (2003). "Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands". Mol. Pathol. 56 (4): 226–31. doi:10.1136/mp.56.4.226. PMC 1187325. PMID 12890744.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE (2007). "HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides". Cancer Immunol. Immunother. 56 (12): 1885–95. doi:10.1007/s00262-007-0331-2. PMID 17487488.