DDX19B

ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.[4][5]

DDX19B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EWS, 3FHC, 3FHT, 3FMO, 3FMP, 3G0H
Identifiers
Aliases	DDX19B, DBP5, DDX19, RNAh, DEAD-box helicase 19B
External IDs	OMIM: 605812 MGI: 2148251 HomoloGene: 56032 GeneCards: DDX19B
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 70,289,663 bp[1] End 70,335,283 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • RNA binding • nucleic acid binding Cellular component • nuclear envelope • nuclear pore • nuclear membrane • extracellular exosome • membrane • cell nucleus • catalytic step 2 spliceosome • nucleolus • cytoplasm Biological process • protein transport • mRNA transport • RNA secondary structure unwinding • mRNA export from nucleus • RNA splicing • regulation of gene expression • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11269	234733
Ensembl	ENSG00000157349	n/a
UniProt	Q9UMR2	n/a
RefSeq (mRNA)	NM_001014449 NM_001014451 NM_001257172 NM_001257173 NM_001257174 NM_001257175 NM_007242 NM_001363938	NM_001190786 NM_001190800 NM_172284
RefSeq (protein)	NP_001014449 NP_001014451 NP_001244101 NP_001244102 NP_001244103 NP_001244104 NP_009173 NP_001350867	n/a
Location (UCSC)	Chr 16: 70.29 – 70.34 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000157349 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Seraphin B, Carmo-Fonseca M, Izaurralde E (Sep 1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO J. 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMC 1171509. PMID 10428971.
5. "Entrez Gene: DDX19B DEAD (Asp-Glu-Ala-As) box polypeptide 19B".

Further reading

• Mattioni T, Hume CR, Konigorski S, et al. (1992). "A cDNA clone for a novel nuclear protein with DNA binding activity". Chromosoma. 101 (10): 618–24. doi:10.1007/BF00360539. PMID 1424986.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Yin L, Li J, Zhu H, et al. (2003). "Identification and characterization of a gene coding a novel isoform of DEAD-box protein". Reprod. Fertil. Dev. 14 (3–4): 185–9. doi:10.1071/RD01028. PMID 12219940.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.