DCTN4

Dynactin subunit 4 is a protein that in humans is encoded by the DCTN4 gene.[5]

DCTN4
Identifiers
Aliases	DCTN4, DYN4, P62, dynactin subunit 4
External IDs	OMIM: 614758 MGI: 1914915 HomoloGene: 9430 GeneCards: DCTN4
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,708,440 bp[1] End 150,759,109 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D3 Start 60,526,185 bp[2] End 60,558,766 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protein N-terminus binding Cellular component • cytoplasm • cytosol • centrosome • cytoplasmic dynein complex • cytoskeleton • cell nucleus • dynactin complex • microtubule organizing center • kinetochore • spindle pole • stress fiber • focal adhesion • cell cortex • sarcomere Biological process • ER to Golgi vesicle-mediated transport • nuclear migration • antigen processing and presentation of exogenous peptide antigen via MHC class II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51164	67665
Ensembl	ENSG00000132912	ENSMUSG00000024603
UniProt	Q9UJW0	Q8CBY8
RefSeq (mRNA)	NM_001135643 NM_001135644 NM_016221	NM_026302 NM_001357462
RefSeq (protein)	NP_001129115 NP_001129116 NP_057305	NP_080578 NP_001344391
Location (UCSC)	Chr 5: 150.71 – 150.76 Mb	Chr 18: 60.53 – 60.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132912 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024603 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Dynactin 4 (p62)".

Further reading

• Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
• Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, Gibson RL, Bamshad MJ (July 2012). "Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis". Nature Genetics. 44 (8): 886–9. doi:10.1038/ng.2344. PMC 3702264. PMID 22772370.
• Ayalon G, Davis JQ, Scotland PB, Bennett V (December 2008). "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan". Cell. 135 (7): 1189–200. doi:10.1016/j.cell.2008.10.018. PMID 19109891.
• Bingham JB, Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429.
• Lim CM, Cater MA, Mercer JF, La Fontaine S (May 2006). "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A". The Journal of Biological Chemistry. 281 (20): 14006–14. doi:10.1074/jbc.M512745200. PMID 16554302.
• Boultwood J, Fidler C, Strickson AJ, Watkins F, Kostrzewa M, Jaju RJ, Müller U, Wainscoat JS (May 2000). "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs". Genomics. 66 (1): 26–34. doi:10.1006/geno.2000.6193. PMID 10843801.