DAZL

Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.[3]

DAZL
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDAZL, DAZH, DAZL1, DAZLA, SPGYLA, deleted in azoospermia like
External IDsOMIM: 601486 HomoloGene: 1034 GeneCards: DAZL
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p24.3Start16,586,792 bp[1]
End16,670,306 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1618

n/a

Ensembl

ENSG00000092345

n/a

UniProt

Q92904

n/a

RefSeq (mRNA)

NM_001351
NM_001190811

n/a

RefSeq (protein)

NP_001177740
NP_001342

n/a

Location (UCSC)Chr 3: 16.59 – 16.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.[4]

In mice and pigs deficient in DAZL, PGCs migrate to the gonad but do not undertake germ cell determination, and may instead produce germ cell tumors.[5]

Interactions

DAZL has been shown to interact with DAZ1.[6][7]

gollark: I suppose it's probably just good practice generally.
gollark: They're *fixing* this? *Why* are they fixing this?
gollark: ```bashVID="$1"FILENAME="$(basename "$VID")"TITLE="${FILENAME%.*}"VIDCONF="-vf scale=320:-1 -r 12"VP9X="-c:v libvpx-vp9 -b:v 76k"ffmpeg -i "$VID" $VIDCONF $VP9X -pass 1 -an -f webm -y /dev/null && \ffmpeg -i "$VID" $VIDCONF $VP9X -pass 2 -ac 1 -c:a libopus -b:a 18k -cpu-used 1 -metadata title="$TITLE" -y output.webm```THIS is how you should encode your entire video library.
gollark: Specifically ones I can actually obtain in the UK.
gollark: I have repairability, lifetime, battery life and custom ROM support as high priorities, don't care that much about specs, fancy cameras and whatever.

References
  1. GRCh38: Ensembl release 89: ENSG00000092345 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC (Nov 1996). "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned". Nature Genetics. 14 (3): 292–9. doi:10.1038/ng1196-292. PMID 8896558.
  4. "Entrez Gene: DAZL deleted in azoospermia-like".
  5. Nicholls, Peter K.; Schorle, Hubert; Naqvi, Sahin; Hu, Yueh-Chiang; Fan, Yuting; Carmell, Michelle A.; Dobrinski, Ina; Watson, Adrienne L.; Carlson, Daniel F.; Fahrenkrug, Scott C.; Page, David C. (2019-11-21). "Mammalian germ cells are determined after PGC colonization of the nascent gonad". Proceedings of the National Academy of Sciences. 116 (51): 25677–25687. doi:10.1073/pnas.1910733116. ISSN 0027-8424. PMC 6925976. PMID 31754036.
  6. Ruggiu M, Cooke HJ (Jul 2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene. 252 (1–2): 119–26. doi:10.1016/S0378-1119(00)00219-5. PMID 10903443.
  7. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading


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