DAHANCA

The Danish Head and Neck Cancer Group (DAHANCA) is a permanent working group operating under the authority of the Danish Society for Head and Neck Oncology. It operates an ongoing series of clinical studies regarding head and neck cancers.

DAHANCA receives pharmaceutical industry sponsorship in order to conduct these trials, but it is an independent body, and industry bodies do not have the ability to exert their influence to suppress negative results.

The most recent study was DAHANCA 10 in 2007. DAHANCA 10 was a multicenter, double-blind, randomized, placebo-controlled study on darbepoetin-α (Aranesp, Amgen). The data-monitoring committee recommended early termination of this trial as results were suggesting outcomes were more favourable in the control-group compared to patients receiving the drug.[1]

DAHANCA 5[2] and DAHANCA 6/7[3] were other notable studies conducted by the group.

References
  1. "Results from a multicenter, double-blind, randomized, placebo-controlled study on Aranesp (darbepoetin alfa)". Office of Oncology Drug Products (OODP). U.S. Food and Drug Administration. 2007-02-22. Archived from the original on October 7, 2008. Retrieved 2008-10-14.
  2. Eriksen JG; Overgaard J (2007). "Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study>". Radiotherapy and Oncology. 83 (3): 383–8. doi:10.1016/j.radonc.2007.05.009. PMID 17543403.
  3. Overgaard J; Hansen HS; Specht L; et al. (2003). "Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial". Lancet. 362 (9388): 933–40. doi:10.1016/S0140-6736(03)14361-9. PMID 14511925.



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