Cytokine adsorbing column

Cytokine-adsorbing columns remove inflammatory toxins from the body.[1] Such technology is currently being studied in more than 53 countries, including to treat sepsis in the European Union.[1][2] Specific products include the brand names Cytosorb by Cytosorbents, Lixelle, and Toraymyxin among others.[1]

Their use is currently experimental; early clinical trials have generally failed to show significant improvement in survival, most significantly the EUPHRATES trial[3].

Using cytokine-adsorbing columns involves channeling the patient's blood through a cartridge containing millions of minuscule polymer beads which trap toxins and inflammatory proteins. For this reason, the technology can only be used in conjunction with an additional blood pump system, like a dialysis machine or a heart-lung machine.[2]

The US Air Force is funding a $3 million FDA approved randomized controlled trial in trauma and rhabdomyolysis.[4][5]

References
  1. Honore, PM; Jacobs, R; Joannes-Boyau, O; De Regt, J; De Waele, E; van Gorp, V; Boer, W; Verfaillie, L; Spapen, HD (2013). "Newly designed CRRT membranes for sepsis and SIRS--a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review". ASAIO Journal. 59 (2): 99–106. doi:10.1097/mat.0b013e3182816a75. PMID 23438770.
  2. "This Cartridge of Plastic Beads Can Filter Blood During Surgery". www.bloomberg.com. Retrieved 2018-09-10.
  3. Dellinger, R. Phillip; Bagshaw, Sean M.; Antonelli, Massimo; Foster, Debra M.; Klein, David J.; Marshall, John C.; Palevsky, Paul M.; Weisberg, Lawrence S.; Schorr, Christa A.; Trzeciak, Stephen; Walker, Paul M. (2018-10-09). "Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial". JAMA. 320 (14): 1455–1463. doi:10.1001/jama.2018.14618. ISSN 0098-7484.
  4. "Biotech Product Geared Toward Reducing Deaths in the ICU". Sentinel. Archived from the original on 7 June 2014. Retrieved 9 April 2014.
  5. "Extracorporeal Therapy for the Removal of Myoglobin Using the CytoSorb in Patients With Rhabdomyolysis". clinicaltrials.gov. Retrieved 6 May 2014.
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