Cytokeratin 5/6 antibodies

Cytokeratin 5/6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6.[1] These are used in immunohistochemistry, often called CK 5/6 staining,[2] including the following applications:

  • Identifying basal cells or myoepithelial cells in the breast and prostate.[1]
  • For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative.[1] Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary carcinoma (Cyclin D1 > 37.00%, CK 5/6 negative).[2]
  • In the lung, distinguishing epithelioid mesothelioma (CK5/6 positive in 83%) from lung adenocarcinoma (CK5/6 negative in 85%).[1]

References
  1. Robert Terlević, Semir Vranić. "Cytokeratin 5/6". Topic Completed: 3 June 2019. Revised: 8 December 2019
  2. Wang, Yu; Zhu, Jin-fu; Liu, Ying-ying; Han, Gui-ping (2013). "An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas". Diagnostic Pathology. 8 (1). doi:10.1186/1746-1596-8-8. ISSN 1746-1596.


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