CredibleMeds

CredibleMeds is an online database of independent information regarding the safe use of medicines.[1] The database, launched in 2009, helps to detect serious drug-drug interactions, especially those associated with QT prolongation or the potentially lethal arrhythmia, torsades de pointes (TdP).[2][3][4][5][6] It also assists with measurement of the quality of healthcare delivery for the Centers for Medicare and Medicaid Services, and aids in the management of patients with inherited channelopathies.[7][8]

The overall goal of CredibleMeds is to support efforts to improve the safe use of medicines.

History

The Arizona Center for Education and Research on Therapeutics (AZCERT) maintains the CredibleMeds database. Founded in 2000 at the University of Arizona as part of a network of 14 federally-funded CERTs,[9] AZCERT became a separate non-profit corporation in 2012 funded by the US Food and Drug Administration (FDA), research grants, and charitable contributions. AZCERT focuses on drugs and drug–drug interactions, especially those that cause QT prolongation and Torsades de Pointes (TdP) arrhythmia, and provides its research and its lists of drugs[10] free of charge to the public, healthcare providers, and researchers for personal, professional, and non-commercial purposes. To maintain the independence of its work, AZCERT does not receive funding from companies that have a commercial interest in medications.

Adverse drug event analysis

AZCERT developed the Adverse Drug Event Causality Analysis (ADECA) to evaluate drugs for their risk of causing QT prolongation and TdP.[11] As part of its ADECA reviews, AZCERT includes drugs marketed outside the United States, especially in Europe, Japan, and Canada. In addition to their use to inform healthcare decision making, CredibleMeds’ lists of drugs have been used in research published in more than 50 scientific articles.[12][13][14][15]

gollark: Hmm...
gollark: <@356209633313947648> ```- Fortunes/Dwarf Fortress output/Chuck Norris jokes on boot (wait, IS this a feature?)- (other) viruses (how do you get them in the first place? running random files like this?) cannot do anything particularly awful to your computer - uninterceptable (except by crashing the keyboard shortcut daemon, I guess) keyboard shortcuts allow easy wiping of the non-potatOS data so you can get back to whatever nonsense you do fast- Skynet (rednet-ish stuff over websocket to my server) and Lolcrypt (encoding data as lols and punctuation) built in for easy access!- Convenient OS-y APIs - add keyboard shortcuts, spawn background processes & do "multithreading"-ish stuff.- Great features for other idio- OS designers, like passwords and fake loading (est potatOS.stupidity.loading [time], est potatOS.stupidity.password [password]).- Digits of Tau available via a convenient command ("tau")- Potatoplex and Loading built in ("potatoplex"/"loading") (potatoplex has many undocumented options)!- Stack traces (yes, I did steal them from MBS)- Backdoors- er, remote debugging access (it's secured, via ECC signing on disks and websocket-only access requiring a key for the other one)- All this useless random junk can autoupdate (this is probably a backdoor)!- EZCopy allows you to easily install potatOS on another device, just by sticking it in the disk drive of any potatOS device!- fs.load and fs.dump - probably helpful somehow.- Blocks bad programs (like the "Webicity" browser).- Fully-featured process manager.- Can run in "hidden mode" where it's at least not obvious at a glance that potatOS is installed.- Convenient, simple uninstall with the "uninstall" command.- Turns on any networked potatOS computers!- Edits connected signs to use as ad displays.- A recycle bin.- An exorcise command, which is like delete but better.- Support for a wide variety of Lorem Ipsum.```
gollark: Okay, that is... probably a better idea, yes.
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gollark: Oh, probably, but this I can actually understand.

References
  1. Woosley RL, Black K, Heise CW, Romero K. CredibleMeds.org: What does it offer? Trends in Cardiovascular Medicine. 2017;28.2:94-99.
  2. Schepker K. “CredibleMeds” – New Private-Public Project Aims to Reduce Antibiotic Side-Effects. Holistic Primary Care-News for Health & Healing. Published 19 October 2016. https://holisticprimarycare.net/topics/topics-h-n/holistech/1837-crediblemeds-new-private-public-collaboration-aims-to-reduce-inappropriate-antibiotic-use.html (accessed 18 June 2019).
  3. Poluzzi E, Raschi E, Diemberger I, De Ponti F. Drug-Induced Arrhythmia: Bridging the Gap Between Pathophysiological Knowledge and Clinical Practice. Drug Safety. 2017;40:461-4.
  4. CredibleMeds. The Journal of QT informatics. http://qtinformatics.com/crediblemeds/ Archived 2019-06-16 at the Wayback Machine (accessed 18 June 2019).
  5. CredibleMeds Filtered QTDrug List. Continuing Pharmacy Professional Development. The University of British Columbia Faculty of Pharmaceutical Sciences. https://cpd.pharmacy.ubc.ca/sites/cpd.pharmacy.ubc.ca/files/uploads/Update_2016/DLi_WS4_Drug_Interact/CredibleMeds%20Filtered%20QTDrug%20List%20Feb%2021%2C%202016.pdf (accessed 18 June 2019).
  6. Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes. Sudden Arrhythmia Death Syndromes (SADS) Foundation. https://www.sads.org/living-with-sads/Drugs-to-Avoid#.XQZzNY97nIU (accessed 18 June 2019).
  7. Al-Khatib SM, LaPointe NM, Kramer JM, Califf, RM. What Clinicians Should Know About the QT Interval. Journal of American Medicine Association. 2003;289:2120-7.
  8. LaPointe NM, Al-Khatib SM, Kramer JM, Califf RM. [https://doi.org/10.1046/j.1542-474X.2003.08211.x Knowledge Deficits Related to the QT Interval Could Affect Patient Safety. Annals of Noninvasive Electrocardiology. 2003;8:157-60.
  9. Reidenberg MM. Centers for Education and Research in Therapeutics. Clinical Pharmacology and Therapeutics (2000) 68:109-10.
  10. QTdrugs.org
  11. Schwartz PJ, Woosley RL. Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes. Journal of the American College of Cardiology (2016) 67.13:1639-1650.
  12. Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes. Heart. 2003;89(11):1363–1372. doi:10.1136/heart.89.11.1363
  13. Miranda DG, McMain CL, Smith AJ. Medication-induced QT-interval prolongation and torsades de pointes. US Pharm. 2011;36(2):HS-2-HS-8.
  14. Krantz MJ, Martin J, Stimmel B, Mehta D, Haigney MC. QTc interval screening in methadone treatment. Annals of Internal Medicine. 2009;150:387–395. doi: 10.7326/0003-4819-150-6-200903170-00103
  15. Medsafe. Drug-induced QT prolongation and torsades de pointes - the facts. Prescriber Update 2010;31(4): 27-29. https://www.medsafe.govt.nz/profs/PUArticles/PDF/Prescriber%20Update%20Dec%202010.pdf (accessed 18 June 2019).
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