Crc (protein)

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. [2]Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted.[3] Crc-mediated regulation impact processes such as biofilm formation,[4] virulence [5] and antibiotic susceptibility.[6]

Crc
Crystal structure of Crc in Pseudomonas aeruginosa.[1]
Identifiers
SymbolCrc
PfamPF03372
CDDcd08372

Interactions
A consensus sequence targeted by Crc mediated regulation

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.[7]

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gollark: processor : 0vendor_id : AuthenticAMDcpu family : 23model : 1model name : AMD Ryzen 3 1200 Quad-Core Processorstepping : 1microcode : 0x800111ccpu MHz : 3410.279cache size : 512 KBphysical id : 0siblings : 4core id : 0cpu cores : 4apicid : 0initial apicid : 0fpu : yesfpu_exception : yescpuid level : 13wp : yesflags : fpu vme de pse tsc msr pae mce cx8 apic sep mtrr pge mca cmov pat pse36 clflush mmx fxsr sse sse2 ht syscall nx mmxext fxsr_opt pdpe1gb rdtscp lm constant_tsc rep_good nopl nonstop_tsc cpuid extd_apicid aperfmperf pni pclmulqdq monitor ssse3 fma cx16 sse4_1 sse4_2 movbe popcnt aes xsave avx f16c rdrand lahf_lm cmp_legacy svm extapic cr8_legacy abm sse4a misalignsse 3dnowprefetch osvw skinit wdt tce topoext perfctr_core perfctr_nb bpext perfctr_llc mwaitx cpb hw_pstate sme ssbd sev vmmcall fsgsbase bmi1 avx2 smep bmi2 rdseed adx smap clflushopt sha_ni xsaveopt xsavec xgetbv1 xsaves clzero irperf xsaveerptr arat npt lbrv svm_lock nrip_save tsc_scale vmcb_clean flushbyasid decodeassists pausefilter pfthreshold avic v_vmsave_vmload vgif overflow_recov succor smcabugs : sysret_ss_attrs null_seg spectre_v1 spectre_v2 spec_store_bypassbogomips : 6989.20TLB size : 2560 4K pagesclflush size : 64cache_alignment : 64address sizes : 43 bits physical, 48 bits virtualpower management: ts ttp tm hwpstate eff_freq_ro [13] [14]
gollark: I mean, you might accidentally hack into the pentagon, and then if you hit the virtual firewall they'll backtrace your IP with visual basic.
gollark: Yes, well.
gollark: `/usr/bin/hack --master /dev/fbi`

References
  1. Wei Y, Zhang H, Gao ZQ, Xu JH, Liu QS, Dong YH (January 2013). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life. 65 (1): 50–7. doi:10.1002/iub.1103. PMID 23281037.
  2. Ramos, Juan-Luis (2004-06-17). Virulence and Gene Regulation. Springer Science & Business Media. ISBN 978-0-306-48376-9.
  3. Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLoS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720. PMID 24945892.
  4. O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa". J Bacteriol. 182 (2): 425–431. doi:10.1128/jb.182.2.425-431.2000. PMC 94292.
  5. Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G (December 2012). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology. 158 (Pt 12): 3014–9. doi:10.1099/mic.0.061192-0. PMID 23023972.
  6. Yeung AT, Bains M, Hancock RE (February 2011). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". Journal of Bacteriology. 193 (4): 918–31. doi:10.1128/jb.00911-10. PMC 3028677. PMID 21169488.
  7. Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLoS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720. PMID 24945892.
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