Neomycin/polymyxin B/hydrocortisone

Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[2][3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[3] It is used as an ear drop or eye drop.[2][3]

Neomycin/polymyxin B/hydrocortisone
Combination of
NeomycinAntibiotic
Polymyxin BAntibiotic
HydrocortisoneGlucocorticoid
Clinical data
Trade namesOtosporin, Cortisporin, others
AHFS/Drugs.comFDA Professional Drug Information
Pregnancy
category
    Routes of
    administration    		Ear drop, ear drop
    Legal status
    Legal status
    Identifiers
    KEGG

    The most common side effects include itchiness and a skin rash.[4] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[2][4] Safety in pregnancy and breastfeeding is unclear.[1] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[5]

    The combination was approved for medical use in the United States in 1964.[3] In the United Kingdom a 10 ml bottle costs the NHS about £7.45 as of 2019.[2] In the United States the wholesale cost of this amount is about US$50.[6] In 2017, it was the 304th most commonly prescribed medication in the United States, with more than one million prescriptions.[7]

    History

    Cortisporin was developed by Glaxo Wellcome and was approved by the Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[8]

    Cost

    In David Lazarus' February 4, 2016 LA Times column, a pharmacist recalled a 10 milliliter vial of the drug selling for around $10 in the early 2010s. In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[8] The drug is owned by Dublin, Ireland-based Endo International.

    Formulations

    Generic name: neomycin sulfate, polymyxin B sulfate, and hydrocortisone
    Dosage form: otic suspension (liquid with ear dropper)
    Generic name: neomycin sulfate, polymyxin B sulfate, bacitracin zinc and hydrocortisone
    Dosage form: Dermatological ointment, drops

    gollark: Although I had to have spaghetti instead of pasta which was a great injustice.
    gollark: I mean, over here we've been hit by COVID-19™ and all but still have food, despite only keeping something like a few days stocked.
    gollark: Your body digests your muscles and eventually organs, you see, for energy.
    gollark: You won't ENJOY it, but you won't be DEAD either!
    gollark: Technically, you won't *die* without food for several WEEKS.

    References
    1. "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
    2. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
    3. "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
    4. "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
    5. "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
    6. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
    7. "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
    8. Lazarus, David (2016-02-04). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". latimes.com. Retrieved 2016-02-05.
    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.