Copper fist

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1co4

Copper fist domain
	Structure of a zinc domain conserved in yeast copper-regulated transcription factors.[1]
Identifiers
Symbol	Copper fist
Pfam	PF00649
InterPro	IPR001083
SMART	SM00412
PROSITE	PS50073
SCOPe	1co4 / SUPFAM
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1co4

Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist.

It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.

External links

Copper fist definition

References

Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR (July 1998). "Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors". Nat. Struct. Biol. 5 (7): 551–5. doi:10.1038/805. PMID 9665167.

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[pmid9665167-1] Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR (July 1998). "Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors". Nat. Struct. Biol. 5 (7): 551–5. doi:10.1038/805. PMID 9665167.