Congenital contractural arachnodactyly in cattle

Congenital contractural arachnodactyly (CA), also known as fawn calf syndrome, is an autosomal recessive genetic disorder in cattle.[1] The disorder affects the connective tissue of muscles,[1] leading to contracture of the upper limb (most obvious in the hind limbs), and laxity of the joints of the lower limbs.[2] CA affects Angus cattle, and associated breeds such as Murray Greys.[3] The mutation which causes this defect is a deletion on bovine chromosome 21.[3]

Clinical signs

Affected calves are usually born alive with normal body weight, and most are able to walk and suckle, although 20 percent cannot suckle and die soon after birth.[1] Signs include proximal limb contracture, congenital distal limb hyperextension and congenital kyphosis.[1] As the calf grows, signs significantly improve.[1] In mildly affected calves, CA may be less obvious, presenting as tall stature, joint laxity and poor muscling.[4] Joint laxity predisposes affected cattle to the early onset of arthritis.[4]

Prevention

In Australia, affected animals are descended from Freestate Barbara 871 of Kaf, a cow born in Indiana, US, in 1978. This cow is an ancestor of approximately half of all Angus cattle in Australia, limiting the usefulness of pedigree analysis in identifying potential carriers.[2] If CA is identified in a herd, bulls which have tested negative for CA should be purchased, since both parents must be carriers of the defective gene for affected calves to be born.[2] Angus sires which carry CA include Rambo 465T of JRS, Te Mania Kelp K207, Bon View Bando 598, SAF 598 Bando 5175 and Boyd On Target 1083.[2]

History

The disorder was first identified in Victoria, Australia in 1998, and has since been identified in other countries.[1] A genetic test was developed in 2010.[4]

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References
  1. Whitlock, Brian K. "Heritable birth defects in cattle" (PDF). Department of Large Animals Clinical Sciences, University of Tennessee. Retrieved 2013-11-05.
  2. Denholm, Laurence (May 2010). "Congenital contractural arachnodactyly in Angus cattle" (PDF). No. PRIMEFACT 1015. NSW Department of Primary Industries. Retrieved 2018-03-10. Cite magazine requires |magazine= (help)
  3. "OMIA 001511-9913 : Contractural arachnodactyly (Fawn calf syndrome) in Bos taurus". OMIA - Online Mendelian Inheritance in Animals. Retrieved 2018-03-10.
  4. Tammen, I.; Khatkar, M.S.; Cavanagh, J.A.L.; Windsor, P.A.; Thomson, P.C.; Raadsma, H.W. (2011). "Mapping of congenital contractural arachnodactyly in cattle" (PDF). Association for the Advancement of Animal Breeding and Genetics. 19: 215–218.
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