Colon cancer associated transcript 1 (non-protein coding)

Colon cancer associated transcript 1 (non-protein coding) is a protein that, in humans, is encoded by the CCAT1 gene. [2][3]

CCAT1
Identifiers
Aliases	CCAT1, CARLo-5, onco-lncRNA-40, colon cancer associated transcript 1 (non-protein coding), CARLO5, colon cancer associated transcript 1
External IDs	OMIM: 617705 GeneCards: CCAT1
Orthologs
Species	Human	Mouse
Entrez	100507056	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata
View/Edit Human

This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types.[4] This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus[5]. This RNA may also function as a molecular sponge for microRNAs[6].

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Entrez Gene: Colon cancer associated transcript 1 (non-protein coding)". Retrieved 2017-03-16.
3. "CCAT2 colon cancer associated transcript 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-06-13.
4. "CCAT1 Gene - GeneCards | CCAT1 RNA Gene". www.genecards.org. Retrieved 2020-06-29.
5. "CCAT1 colon cancer associated transcript 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-06-29.
6. "CCAT1 Gene - GeneCards | CCAT1 RNA Gene". www.genecards.org. Retrieved 2020-06-29.

Further reading

• Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013). "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma". J. Cancer Res. Clin. Oncol. 139 (3): 437–45. doi:10.1007/s00432-012-1324-x. PMID 23143645.
• Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A (2013). "Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence". BMC Cancer. 13: 196. doi:10.1186/1471-2407-13-196. PMC 3639026. PMID 23594791.
• Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X, Yang L, Chen LL (2014). "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus". Cell Res. 24 (5): 513–31. doi:10.1038/cr.2014.35. PMC 4011346. PMID 24662484.
• Luo J, Tang L, Zhang J, Ni J, Zhang HP, Zhang L, Xu JF, Zheng D (2014). "Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer". Tumour Biol. 35 (11): 11541–9. doi:10.1007/s13277-014-2442-7. PMID 25129441.
• Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015). "Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p". Cell Death Dis. 6: e1583. doi:10.1038/cddis.2014.541. PMC 4669740. PMID 25569100.
• Zhang Y, Ma M, Liu W, Ding W, Yu H (2014). "Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer". Int J Clin Exp Pathol. 7 (12): 8471–9. PMC 4314006. PMID 25674211.
• Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA (2015). "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function". RNA Biol. 12 (6): 628–42. doi:10.1080/15476286.2015.1038012. PMC 4615893. PMID 25864709.
• Deng L, Yang SB, Xu FF, Zhang JH (2015). "Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge". J. Exp. Clin. Cancer Res. 34: 18. doi:10.1186/s13046-015-0136-7. PMC 4339002. PMID 25884472.
• Zhu H, Zhou X, Chang H, Li H, Liu F, Ma C, Lu J (2015). "CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion". Int J Clin Exp Pathol. 8 (5): 5427–34. PMC 4503117. PMID 26191246.