Cohesin domain

In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.[1]

Cohesin
single cohesin domain from the scaffolding protein cipa of the clostridium thermocellum cellulosome
Identifiers
SymbolCohesin
PfamPF00963
Pfam clanCL0203
InterProIPR002102
SCOPe1anu / SUPFAM
CDDcd08546

The scaffoldin component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.

References

  1. Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, Frolow F (March 1997). "A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly". Structure. 5 (3): 381–90. doi:10.1016/s0969-2126(97)00195-0. PMID 9083107.
This article incorporates text from the public domain Pfam and InterPro: IPR002102
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