Clitocine

Clitocine is a mushroom nucleoside isolate with anticancer activity in vitro.[1][2][3]

Clitocine

Names
IUPAC name (2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
Identifiers
CAS Number	105798-74-1
3D model (JSmol)	Interactive image
ChemSpider	114380
PubChem CID	129111
CompTox Dashboard (EPA)	DTXSID30909739
SMILES C1=NC(=C(C(=N1)N[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)[N+](=O)[O-])N
Properties
Chemical formula	C9H13N5O6
Molar mass	287.232 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References

1. "Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis". 262 (2). April 2008: 190–200. doi:10.1016/j.canlet.2007.12.013. PMID 18222036. Cite journal requires |journal= (help)
2. "Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line". PLoS ONE. 7 (8): e40720. 2012. doi:10.1371/journal.pone.0040720. PMC 3425549. PMID 22927901.
3. "Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo". Apoptosis. 19 (5): 871–82. May 2014. doi:10.1007/s10495-014-0969-0. PMID 24563182.