Clamoxyquine
Clamoxyquine (INN) or clamoxyquin (former BAN), as the pamoate or hydrochloride salt, is an antiamebic and antidiarrheal drug.
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| Formula | C17H24ClN3O |
| Molar mass | 321.85 g·mol−1 |
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It has been used as a veterinary medicine to treat salmonids for infection with the myxozoan parasite Myxobolus cerebralis.
Synthesis
Antimalarial activity also predominates in a quinoline that bears a diaminoalkyl side chain at a rather different position from the other agents noted.
Clamoxyquin synthesis:[1]
Thus, Mannich condensation of the hydroxyquinoline (1) with formaldehyde and N,N-diethylpropylenediamine affords clamoxyquin (2).
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References
- Burckhalter, J. H.; Brinigar, W. S.; Thompson, P. E. (1961). "Antiamebic Agents. V.1Promising Basic Amebicides Derived from 5-Chloro-8-quinolinol". The Journal of Organic Chemistry. 26 (10): 4070. doi:10.1021/jo01068a103.
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