Christos Socrates Mantzoros

Christos Socrates Mantzoros is a Greek American physician scientist, internist - endocrinologist, teacher, researcher, Harvard Medical School professor and the editor-in-chief of the journal Metabolism: Clinical and Experimental. He is considered a pioneer and worldwide expert in obesity and metabolism. He has given more than 500 lectures nationally and internationally on these critical topics. His research has resulted in more than 800 publications in Medline, including more than 150 publications under the collaborative Look Ahead Research Group, more than 200 chapters and reviews and has received more than 93,000 citations with an h-index=127 (Google Scholar) as well as prestigious awards at national and international meetings.[1][2]

Christos Socrates Mantzoros

Personal

Christos S. Mantzoros was born in Nafplio, Greece and graduated with MD and received a DSc from the University of Athens Medical School. He completed a residency in Internal Medicine at Wayne State University and a fellowship in Endocrinology, Metabolism and Diabetes at the Beth Israel Deaconess Medical Center and Joslin Diabetes Center program of Harvard Medical School. He also received master's degrees in Clinical Epidemiology from the Harvard School of Public Health and Clinical Investigation from Harvard Medical School. He is Board Certified in Internal Medicine and in Endocrinology, Metabolism and Diabetes as well as in Clinical Nutrition. He went rapidly through the academic hierarchy steps from Instructor to Full Professor of Internal Medicine at Harvard University within twelve years.

Research

His work spans the entire spectrum from animal physiology and molecular biology, through observational, epidemiology studies, to physiology and pharmacokinetic interventional proof-of-concept clinical trials on new therapeutic agents important in the treatment of obesity, diabetes and other metabolic diseases in humans.[3] Dr. Christos Mantzoros is known for his groundbreaking work on leptin (see Leptin below) and adiponectin and the relationship between IGF-1 and cancer (see Epidemiology of Cancer below). Recent major contributions of his research group include the elucidation of the physiological role and potential diagnostic and therapeutic utility of several adipokines and myokines, leptin, adiponectin, in human physiology and pathophysiology.[3][4] Leptin has been approved by the Food and Drugs Administration for lipodystrophy and severe insulin resistance accompanied by hyperglycemia and hyperlipidemia.[3] His work has resulted in patents for diagnostic and therapeutic applications and has directly contributed to the development of new pharmaceuticals by major pharmaceutical companies. Currently, he and his team are utilizing various interventions (physiological, pharmacological and dietary) and tools (hormonal, neurocognitive and neuroimaging, functional MRI) to investigate the role of the human brain in regulating energy homeostasis, obesity and metabolism (See Neuroimaging Studies below).

In 2018, Dr. Mantzoros gave a Harvard Medical School Mini Med lecture to teach medical concepts to a lay audience. The lecture was attended by close to 100,000 people from all over the world through live-streaming.[5][6]

Leptin

In the area of leptin, Mantzoros pioneered physiology studies, conducted clinical trials in humans, and discovered its therapeutic potential. He was the first to investigate the normal physiology of leptin in humans, including circadian rhythms and the role of leptin in fasting and with relation to body weight.[7][8][7][9][10][11][12] His team has published the only three studies on leptin pharmacokinetics determining leptin doses to be used in humans. Indeed, his research broadened the understanding of the neuroendocrine function of leptin on body weight, energy homeostasis, gender differentiation, immunology and the interaction with other hormones, such as thyroid stimulating hormone and sex steroids. Observing that hypothalamic amenorrhea (HA) and lipodystrophy were conditions of hypoleptinemia, he piloted clinical trials to test the efficacy of leptin to treat these conditions, showing that leptin replacement in patients with HA and lipodystrophy resulted in complete normalization of hormone axes and bone density in HA as well as insulin resistance and metabolic regulation in lipodystrophy.[10][11][13][14][15][16][17][18][19][20] Additionally, he observed that functional changes in how the brain views food occur in subjects with hypoleptinemia and that these can be corrected with leptin replacement.[21] Dr. Mantzoros and his team observed that short-term metreleptin treatment enhanced activity in areas detecting the salience and rewarding value of food during fasting, while long-term treatment decreased attention to and the rewarding value of food after feeding. Furthermore, hypothalamic activity is modulated by metreleptin treatment and leptin decreases functional connectivity of the hypothalamus to key feeding-related areas in these hypoleptinemic subjects. These findings expanded the role of leptin into systemic neuroendocrine regulation.

Epidemiology of cancer

Observing that the incidence of certain cancers increases with the rate of obesity (e.g. cancers which have been linked with obesity such as endometrial, esophageal, breast, etc.), Dr. Mantzoros hypothesized that insulin-like growth factor 1 (IGF-1) which is also found at higher levels in obesity and a growth factor might be related to the development of cancer. Indeed, he first confirmed in a case-control study that IGF-1 was linked with prostate cancer.[22][23][24] Later, he confirmed a similar link between IGF-1 and other types of cancers, including thyroid, breast, and others both in case control and prospective epidemiology studies.[25][25][26][27] This work opened the way for efforts to develop molecules blocking IGF-1 signaling as possible treatments for cancer, currently being tested.

Additionally, observing the links between insulin resistance, inflammation, and sex steroids with central obesity and obesity-related cancers, Dr. Mantzoros expanded this research to the molecule adiponectin, hypothesizing that abnormalities in this molecule, caused by abnormal fat deposition in the abdomen, were upstream of all other hormonal and inflammatory abnormalities above. First performing physiology studies in rodents and later in human case-control and prospective cohort studies, his team demonstrated the link between adiponectin and several types of cancer, including breast, colorectal, thyroid, prostate, and others.[25][25][26][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] This work opened the way for efforts to develop molecules blocking IGF-1 signaling as possible treatments for cancer, currently being tested.

The Mantzoros group also demonstrated a direct effect of adiponectin and adiponectin receptors on endometrial cancer in humans and started mapping the molecular pathways downstream of adiponectin in malignancies.[35] This suggests that adiponectin regulation may be at the root of obesity-related cancers. Due in large part to this research, adiponectin receptor agonists and/or medications that increase circulating levels of adiponectin are currently being tested as a treatment for cancers related to insulin resistance and central obesity.

Mediterranean Diet

Dr. Mantzoros also demonstrated that following a Mediterranean Diet, which is high in whole-grain cereals and low-fat dairy products and low consumption of refined cereals, leads to improved levels of adipokines like adiponectin, which decreases insulin resistance, and inflammatory factors like c-reactive protein, and thus leads in the long-term to lower incidence of death from cardiovascular disease and stroke.[55][56][57][58][59][60][61]

Neuroimaging studies

Most recently, Dr. Mantzoros has been working on the interplay of hormones and environmental factors to influence the function of brain centers important in energy homeostasis and metabolism and how these may be altered with pharmaceuticals to treat obesity. Focusing on the human brain, he studies the control of eating behaviors as they are affected in obesity in the human cortex.[62] Most significantly, he determined the role of GLP-1 in the human brain. When Dr. Mantzoros and his team examined the GLP-1 analog liraglutide in diabetic adults and found that liraglutide was decreasing activation in the brain's cortex, the area that increases control and makes individuals more attentive to what they are eating.[63] This suggests that individuals on liraglutide find highly desirable foods less appealing and that the medication might prove an effective weight loss therapy for people who tend to eat foods as a reward, such as when they are stressed. Most recently, Dr. Mantzoros and colleagues examined the serotonin 2c receptor agonist lorcaserin in obese adults and discovered that lorcaserin was decreasing activation in the attention-related parietal and visual cortices in response to highly palatable food cues at 1 week in the fasting state and in the parietal cortex in response to any food cues at 4 weeks in the fed state.[64] Decreases in emotion and salience-related limbic activity, including the insula and amygdala, were attenuated at 4 weeks. In a secondary analysis, they observed that decreases in caloric intake, weight, and BMI correlated with activations in amygdala, parietal and visual cortices at baseline, suggesting that lorcaserin would be of particular benefit to emotional eaters. These studies have important implications for obesity and future therapeutics.

Metabolism: Clinical and Experimental

Metabolism: Clinical and Experimental is a biomedical journal published by Elsevier related to all aspects of metabolism. Metabolism: Clinical and Experimental publishes studies in humans, animal and cellular models. The journal, one with a long history in the field of metabolism, was in decline for several years until 2010. Dr. Mantzoros assumed the position of Editor-in-Chief for the journal Metabolism: Clinical and Experimental in 2010. Under his leadership, the journal has experienced an approximately 20% growth annually in all metrics. The journal's impact factor in 2018 was 6.513 putting it in the top 6% of endocrinology journals (average JIF percentile 94%).[65] Its cited half-life was 9.4 in 2018 placing the journal in the top 5% of its category.[65] The impact factor has been continuously increasing over the past eight years that he has been serving at the helm, from 2 to 6.5 (2018), placing the journal amongst the top 6% of endocrinology, diabetes, and metabolism journals as indexed in Journal Citation Reports. Similarly, cited half-life, or the duration an average paper continues receiving citations, has also increased significantly and in 2018 rose to be in the top 5% of endocrinology, diabetes, and metabolism.

Translation of science into tangible clinical benefits

Dr. Mantzoros consults for several companies as the head of the Mantzoros Consulting, LLC. In 2005, he co-founded Intekrin, Inc. which was later acquired by and merged with Coherus, Inc.[66] These companies are developing a number of biosimilars at several stages of clinical development in humans (one approaching FDA approval) in addition to small molecules for diseases related to insulin resistance (e.g. Diabetes, NAFLD). CHRS-131, just successfully completed Phase II trials in humans for multiple sclerosis.[67] More recently, Dr. Mantzoros has co-founded Pangea, Inc.

Teaching and Mentoring

Dr. Mantzoros currently serves as the Chief of Endocrinology, Diabetes and Metabolism at the VA Boston Healthcare System and the Director of the Human Nutrition Unit at Beth Israel Deaconess Medical Center. He teaches at Harvard Medical School and Boston University School of Medicine. He has closely mentored more than 165 scientists, many of whom are now Full Professors, 1 is now a CEO of a pharmaceutical company, 2 are Chief Medical or Scientific Officers, 1 a Vice President biotechnology companies and several others are currently Assistant and Associate Professors, Executive Directors at pharmaceutical companies or clinicians.

Dr. Mantzoros, an active member of the orthodox church, has served in many roles, including teaching pro bono biomedical ethics at the Hellenic College and Holy Cross School of Theology and serving as a member of the Archdiocesan Advisory Council on Bioethics. He has also served as a board member on the Hellenic College Holy Cross (HCHC) Board of Trustees.

Awards

Christos S. Mantzoros has received several awards. Recently, he received the 2017 Obesity Society TOPS Award, the 2018 Endocrine Society's Outstanding Clinical Investigator Award, the 2018 European Society of Endocrinology highest distinction, i.e. the Geoffrey Harris Award and the 2018 American Society for Nutrition Robert H. Herman Research Award.[68][69] He has also been elected to the American Society for Clinical Investigation (ASCI).[70]

gollark: Growing your own food is hard and impractical if you live in a city or something. This is not really a reasonable standard.
gollark: As planned.
gollark: * with
gollark: Even if it's technically possible to replace the parts - I don't really know the practicality of (un)soldering such things - it is much harder than with sane laptops which SATA ports.
gollark: So no ability to swap those.

References
  1. "Pubmed References for Dr. Mantzoros".
  2. "Mantzoros Christos - Google Scholar Citations". scholar.google.com. Retrieved 2019-07-03.
  3. "Christos Mantzoros, MD, DSc, h.c. mult. PhD".
  4. Huh, Joo Young; Panagiotou, Grigorios; Mougios, Vassilis; Brinkoetter, Mary; Vamvini, Maria T; Schneider, Benjamin E; Mantzoros, Christos S (2012). "FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. MRNA expression and circulating concentrations in response to weight loss and exercise". Metabolism. 61 (12): 1725–38. doi:10.1016/j.metabol.2012.09.002. PMC 3614417. PMID 23018146.
  5. "HMS Mini Med Lectures". Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  6. "Mini Med Lecture Video".
  7. Mantzoros, Christos S; Moschos, Stergios J (1998). "Leptin: In search of role(s) in human physiology and pathophysiology". Clinical Endocrinology. 49 (5): 551–67. doi:10.1046/j.1365-2265.1998.00571.x. PMID 10197068.
  8. Ahima, R. S; Prabakaran, D; Mantzoros, C; Qu, D; Lowell, B; Maratos-Flier, E; Flier, J. S (1996). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–2. doi:10.1038/382250a0. PMID 8717038.
  9. Chan, Jean L; Heist, Kathleen; Depaoli, Alex M; Veldhuis, Johannes D; Mantzoros, Christos S (2003). "The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men". Journal of Clinical Investigation. 111 (9): 1409–21. doi:10.1172/JCI17490. PMC 154448. PMID 12727933.
  10. Roemmich, James N; Clark, Pamela A; Berr, Stuart S; Mai, Vu; Mantzoros, Christos S; Flier, Jeffrey S; Weltman, Arthur; Rogol, Alan D (1998). "Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids". American Journal of Physiology. Endocrinology and Metabolism. 275 (3): E543-51. doi:10.1152/ajpendo.1998.275.3.E543. PMID 9725824.
  11. Chan, Jean L; Wong, Shekman L; Mantzoros, Christos S (2008). "Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States". Clinical Pharmacokinetics. 47 (11): 753–64. doi:10.2165/00003088-200847110-00006. PMC 2737404. PMID 18840030.
  12. Lee, J. H; Chan, J. L; Yiannakouris, N; Kontogianni, M; Estrada, E; Seip, R; Orlova, C; Mantzoros, C. S (2003). "Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: Cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects". The Journal of Clinical Endocrinology & Metabolism. 88 (10): 4848–56. doi:10.1210/jc.2003-030519. PMID 14557464.
  13. Welt, C. K; Chan, J. L; Bullen, J; Murphy, R; Smith, P; Depaoli, A. M; Karalis, A; Mantzoros, C. S (2004). "Recombinant human leptin in women with hypothalamic amenorrhea". New England Journal of Medicine. 351 (10): 987–97. doi:10.1056/NEJMoa040388. PMID 15342807.
  14. Matarese, G; Moschos, S; Mantzoros, C. S (2005). "Leptin in immunology". Journal of Immunology. 174 (6): 3137–42. doi:10.4049/jimmunol.174.6.3137. PMID 15749839.
  15. Licinio, Julio; Mantzoros, Christos; Negrão, Anadré B; Cizza, Giovanni; Wong, Ma-Li; Bongiorno, Peter B; Chrousos, George P; Karp, Brian; Allen, Christine; Flier, Jeffrey S; Gold, Philip W (1997). "Human leptin levels are pulsatile and inversely related to pituitary–ardenal function". Nature Medicine. 3 (5): 575–9. doi:10.1038/nm0597-575. PMID 9142131.
  16. Mantzoros, Christos S; Ozata, Metin; Negrao, Andre B; Suchard, Marc A; Ziotopoulou, Mary; Caglayan, Sinan; Elashoff, Robert M; Cogswell, Rebecca J; Negro, Paolo; Liberty, Victoria; Wong, Ma-Li; Veldhuis, Johannes; Ozdemir, I. Caglayan; Gold, Philip W; Flier, Jeffrey S; Licinio, Julio (2001). "Synchronicity of Frequently Sampled Thyrotropin (TSH) and Leptin Concentrations in Healthy Adults and Leptin-Deficient Subjects: Evidence for Possible Partial TSH Regulation by Leptin in Humans". The Journal of Clinical Endocrinology & Metabolism. 86 (7): 3284–91. doi:10.1210/jcem.86.7.7644. PMID 11443202.
  17. Mantzoros, Christos S (2006). "Role of Leptin in Reproduction". Annals of the New York Academy of Sciences. 900: 174–83. doi:10.1111/j.1749-6632.2000.tb06228.x. PMID 10818404.
  18. Mantzoros, Christos; Flier, Jeffrey S; Lesem, Michael D; Brewerton, Timothy D; Jimerson, David C (1997). "Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain1". The Journal of Clinical Endocrinology & Metabolism. 82 (6): 1845–51. doi:10.1210/jcem.82.6.4006. PMID 9177394.
  19. Chan, Jean L; Mantzoros, Christos S (2005). "Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa". The Lancet. 366 (9479): 74–85. doi:10.1016/S0140-6736(05)66830-4. PMID 15993236.
  20. Mantzoros, Christos S (2009). "Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome?". The Journal of Clinical Endocrinology & Metabolism. 94 (4): 1089–1091. doi:10.1210/jc.2009-0340. PMC 2730231. PMID 19349474.
  21. Farr, Olivia M; Fiorenza, Christina; Papageorgiou, Panagiotis; Brinkoetter, Mary; Ziemke, Florencia; Koo, Bang-Bon; Rojas, Rafael; Mantzoros, Christos S (2014). "Leptin Therapy Alters Appetite and Neural Responses to Food Stimuli in Brain Areas of Leptin-Sensitive Subjects Without Altering Brain Structure". The Journal of Clinical Endocrinology & Metabolism. 99 (12): E2529-38. doi:10.1210/jc.2014-2774. PMC 4255115. PMID 25279500.
  22. Wolk, A; Mantzoros, C. S; Andersson, S. O; Bergström, R; Signorello, L. B; Lagiou, P; Adami, H. O; Trichopoulos, D (1998). "Insulin-like growth factor 1 and prostate cancer risk: A population-based, case-control study". Journal of the National Cancer Institute. 90 (12): 911–5. doi:10.1093/jnci/90.12.911. PMID 9637140.
  23. Mantzoros, C. S; Tzonou, A; Signorello, L. B; Stampfer, M; Trichopoulos, D; Adami, H. O (1997). "Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia". British Journal of Cancer. 76 (9): 1115–8. doi:10.1038/bjc.1997.520. PMC 2228109. PMID 9365156.
  24. Wolk, A; Andersson, S. O; Mantzoros, C. S; Trichopoulos, D; Adami, H. O (2000). "Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening?". The Lancet. 356 (9245): 1902–3. doi:10.1016/S0140-6736(00)03266-9. PMID 11130391.
  25. Moschos, S. J; Mantzoros, C. S (2002). "The role of the IGF system in cancer: From basic to clinical studies and clinical applications". Oncology. 63 (4): 317–32. doi:10.1159/000066230. PMID 12417786.
  26. Pazaitou-Panayiotou, Kalliopi; Panagiotou, Grigorios; Polyzos, Stergios A; Mantzoros, Christos S (2016). "Serum Adiponectin and Insulin-Like Growth Factor 1 in Predominantly Female Patients with Thyroid Cancer: Association with the Histologic Characteristics of the Tumor". Endocrine Practice. 22 (1): 68–75. doi:10.4158/EP15814.OR. PMID 26484409.
  27. Larsson, S. C; Mantzoros, C. S; Wolk, A (2007). "Diabetes mellitus and risk of breast cancer: A meta-analysis". International Journal of Cancer. 121 (4): 856–62. doi:10.1002/ijc.22717. PMID 17397032.
  28. Barb, D; Pazaitou-Panayiotou, K; Mantzoros, C. S (2006). "Adiponectin: A link between obesity and cancer". Expert Opinion on Investigational Drugs. 15 (8): 917–31. doi:10.1517/13543784.15.8.917. PMID 16859394.
  29. Inamura, Kentaro; Song, Mingyang; Jung, Seungyoun; Nishihara, Reiko; Yamauchi, Mai; Lochhead, Paul; Qian, Zhi Rong; Kim, Sun A; Mima, Kosuke; Sukawa, Yasutaka; Masuda, Atsuhiro; Imamura, Yu; Zhang, Xuehong; Pollak, Michael N; Mantzoros, Christos S; Harris, Curtis C; Giovannucci, Edward; Fuchs, Charles S; Cho, Eunyoung; Chan, Andrew T; Wu, Kana; Ogino, Shuji (2015). "Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According toKRASMutation Status". Journal of the National Cancer Institute. 108 (4): djv363. doi:10.1093/jnci/djv363. PMC 4668768. PMID 26598515.
  30. Michalakis, Konstantinos; Venihaki, Maria; Mantzoros, Christos; Vazaiou, Andriani; Ilias, Ioannis; Gryparis, Alexandros; Margioris, Andrew N (2015). "In prostate cancer, low adiponectin levels are not associated with insulin resistance". European Journal of Clinical Investigation. 45 (6): 572–8. doi:10.1111/eci.12445. PMID 25833038.
  31. Moon, H.-S; Mantzoros, C. S (2013). "Adiponectin and metformin additively attenuate IL1 -induced malignant potential of colon cancer". Endocrine-Related Cancer. 20 (6): 849–59. doi:10.1530/ERC-13-0240. PMID 24157941.
  32. Dalamaga, Maria; Karmaniolas, Konstantinos; Chamberland, John; Nikolaidou, Athina; Lekka, Antigoni; Dionyssiou-Asteriou, Amalia; Mantzoros, Christos S (2013). "Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome". Metabolism. 62 (12): 1830–9. doi:10.1016/j.metabol.2013.09.007. PMID 24140093.
  33. Kaklamani, Virginia G; Hoffmann, Thomas J; Thornton, Timothy A; Hayes, Geoffrey; Chlebowski, Rowan; Van Horn, Linda; Mantzoros, Christos (2013). "Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative". Breast Cancer Research and Treatment. 139 (2): 461–8. doi:10.1007/s10549-013-2546-6. PMC 3773607. PMID 23624817.
  34. Dalamaga, Maria; Diakopoulos, Kalliope N; Mantzoros, Christos S (2012). "The Role of Adiponectin in Cancer: A Review of Current Evidence". Endocrine Reviews. 33 (4): 547–94. doi:10.1210/er.2011-1015. PMC 3410224. PMID 22547160.
  35. Moon, H.-S; Chamberland, J. P; Aronis, K; Tseleni-Balafouta, S; Mantzoros, C. S (2011). "Direct Role of Adiponectin and Adiponectin Receptors in Endometrial Cancer: In Vitro and Ex Vivo Studies in Humans". Molecular Cancer Therapeutics. 10 (12): 2234–43. doi:10.1158/1535-7163.MCT-11-0545. PMC 3237794. PMID 21980131.
  36. Mitsiades, Nicholas; Pazaitou-Panayiotou, Kalliopi; Aronis, Konstantinos N; Moon, Hyun-Seuk; Chamberland, John P; Liu, Xiaowen; Diakopoulos, Kalliope N; Kyttaris, Vasileios; Panagiotou, Vasiliki; Mylvaganam, Geetha; Tseleni-Balafouta, Sofia; Mantzoros, Christos S (2011). "Circulating Adiponectin is Inversely Associated with Risk of Thyroid Cancer:In Vivoandin Vitro Studies". The Journal of Clinical Endocrinology & Metabolism. 96 (12): E2023-8. doi:10.1210/jc.2010-1908. PMC 3232611. PMID 21937620.
  37. Gialamas, Spyros P; Petridou, Eleni Th; Tseleni-Balafouta, Sofia; Spyridopoulos, Themistoklis N; Matsoukis, Ioannis L; Kondi-Pafiti, Agathi; Zografos, George; Mantzoros, Christos S (2011). "Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer". Metabolism. 60 (11): 1530–8. doi:10.1016/j.metabol.2011.03.020. PMID 21632074.
  38. Petridou, Eleni Th; Sergentanis, Theodoros N; Dessypris, Nick; Vlachantoni, Iris T; Tseleni-Balafouta, Sofia; Pourtsidis, Apostolos; Moschovi, Maria; Polychronopoulou, Sofia; Athanasiadou-Piperopoulou, Fani; Kalmanti, Maria; Mantzoros, Christos S (2009). "Serum Adiponectin As a Predictor of Childhood Non-Hodgkin's Lymphoma: A Nationwide Case-Control Study". Journal of Clinical Oncology. 27 (30): 5049–55. doi:10.1200/JCO.2008.19.7525. PMC 2799057. PMID 19738128.
  39. Dalamaga, Maria; Migdalis, Ilias; Fargnoli, Jessica L; Papadavid, Evangelia; Bloom, Erica; Mitsiades, Nicholas; Karmaniolas, Konstantinos; Pelecanos, Nicolaos; Tseleni-Balafouta, Sofia; Dionyssiou-Asteriou, Amalia; Mantzoros, Christos S (2008). "Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: A case–control study". Cancer Causes & Control. 20 (5): 625–33. doi:10.1007/s10552-008-9273-z. PMC 2720089. PMID 19051043.
  40. Kaklamani, Virginia G; Wisinski, K. B; Sadim, M; Gulden, C; Do, A; Offit, K; Baron, J. A; Ahsan, H; Mantzoros, C; Pasche, B (2008). "Variants of the Adiponectin (<emph type="ital">ADIPOQ</emph>) and Adiponectin Receptor 1 (<emph type="ital">ADIPOR1</emph>) Genes and Colorectal Cancer Risk". JAMA. 300 (13): 1523–31. doi:10.1001/jama.300.13.1523. PMC 2628475. PMID 18827209.
  41. Dalamaga, Maria; Karmaniolas, Konstantinos; Panagiotou, Anna; Hsi, Alex; Chamberland, John; Dimas, Cleanthi; Lekka, Antigoni; Mantzoros, Christos S (2008). "Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: A case–control study". Cancer Causes & Control. 20 (2): 193–9. doi:10.1007/s10552-008-9233-7. PMID 18814045.
  42. Sher, David J; Oh, William K; Jacobus, Susanna; Regan, Meredith M; Lee, Gwo-Shu; Mantzoros, Christos (2008). "Relationship between serum adiponectin and prostate cancer grade". The Prostate. 68 (14): 1592–8. doi:10.1002/pros.20823. PMID 18646046.
  43. Kaklamani, V. G; Sadim, M; Hsi, A; Offit, K; Oddoux, C; Ostrer, H; Ahsan, H; Pasche, B; Mantzoros, C (2008). "Variants of the Adiponectin and Adiponectin Receptor 1 Genes and Breast Cancer Risk". Cancer Research. 68 (9): 3178–84. doi:10.1158/0008-5472.CAN-08-0533. PMC 2685173. PMID 18451143.
  44. Barb, D; Neuwirth, A; Mantzoros, C. S; Balk, S. P (2007). "Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway". Endocrine-Related Cancer. 14 (4): 995–1005. doi:10.1677/ERC-06-0091. PMID 18045951.
  45. Mantzoros, C. S; Trakatelli, M; Gogas, H; Dessypris, N; Stratigos, A; Chrousos, G. P; Petridou, E. T (2007). "Circulating adiponectin levels in relation to melanoma: A case-control study". European Journal of Cancer. 43 (9): 1430–6. doi:10.1016/j.ejca.2007.03.026. PMID 17512191.
  46. Tworoger, S. S; Eliassen, A. H; Kelesidis, T; Colditz, G. A; Willett, W. C; Mantzoros, C. S; Hankinson, S. E (2007). "Plasma adiponectin concentrations and risk of incident breast cancer". The Journal of Clinical Endocrinology & Metabolism. 92 (4): 1510–6. doi:10.1210/jc.2006-1975. PMID 17213279.
  47. Spyridopoulos, T. N; Petridou, E. T; Skalkidou, A; Dessypris, N; Chrousos, G. P; Mantzoros, C. S; Obesity Cancer Oncology Group (2007). "Low adiponectin levels are associated with renal cell carcinoma: A case-control study". International Journal of Cancer. 120 (7): 1573–8. doi:10.1002/ijc.22526. PMID 17205522.
  48. Kelesidis, I; Kelesidis, T; Mantzoros, C. S (2006). "Adiponectin and cancer: A systematic review". British Journal of Cancer. 94 (9): 1221–5. doi:10.1038/sj.bjc.6603051. PMC 2361397. PMID 16570048.
  49. Petridou, E; Mantzoros, C. S; Dessypris, N; Dikalioti, S. K; Trichopoulos, D (2006). "Adiponectin in relation to childhood myeloblastic leukaemia". British Journal of Cancer. 94 (1): 156–60. doi:10.1038/sj.bjc.6602896. PMC 2361080. PMID 16404369.
  50. Wei, E. K; Giovannucci, E; Fuchs, C. S; Willett, W. C; Mantzoros, C. S (2005). "Low plasma adiponectin levels and risk of colorectal cancer in men: A prospective study". Journal of the National Cancer Institute. 97 (22): 1688–94. doi:10.1093/jnci/dji376. PMID 16288122.
  51. Dal Maso, L; Augustin, L. S; Karalis, A; Talamini, R; Franceschi, S; Trichopoulos, D; Mantzoros, C. S; La Vecchia, C (2004). "Circulating adiponectin and endometrial cancer risk". The Journal of Clinical Endocrinology & Metabolism. 89 (3): 1160–3. doi:10.1210/jc.2003-031716. PMID 15001602.
  52. Mantzoros, C; Petridou, E; Dessypris, N; Chavelas, C; Dalamaga, M; Alexe, D. M; Papadiamantis, Y; Markopoulos, C; Spanos, E; Chrousos, G; Trichopoulos, D (2004). "Adiponectin and breast cancer risk". The Journal of Clinical Endocrinology & Metabolism. 89 (3): 1102–7. doi:10.1210/jc.2003-031804. PMID 15001594.
  53. Petridou, E; Mantzoros, C; Dessypris, N; Koukoulomatis, P; Addy, C; Voulgaris, Z; Chrousos, G; Trichopoulos, D (2003). "Plasma adiponectin concentrations in relation to endometrial cancer: A case-control study in Greece". The Journal of Clinical Endocrinology & Metabolism. 88 (3): 993–7. doi:10.1210/jc.2002-021209. PMID 12629074.
  54. Chou, Sharon H; Tseleni-Balafouta, Sofia; Moon, Hyun-Seuk; Chamberland, John P; Liu, Xiaowen; Kavantzas, Nikolaos; Mantzoros, Christos S (2010). "Adiponectin Receptor Expression in Human Malignant Tissues". Hormones and Cancer. 1 (3): 136–45. doi:10.1007/s12672-010-0017-7. PMID 21761356.
  55. Ko, Byung-Joon; Park, Kyung Hee; Mantzoros, Christos S (2014). "Diet patterns, adipokines, and metabolism: Where are we and what is next?". Metabolism. 63 (2): 168–77. doi:10.1016/j.metabol.2013.11.004. PMID 24360751.
  56. Park, Kyung Hee; Zaichenko, Lesya; Peter, Patricia; Davis, Cynthia R; Crowell, Judith A; Mantzoros, Christos S (2014). "Diet quality is associated with circulating C-reactive protein but not irisin levels in humans". Metabolism. 63 (2): 233–41. doi:10.1016/j.metabol.2013.10.011. PMC 4373656. PMID 24315778.
  57. Mantzoros, Christos S; Sweeney, Laura; Williams, Catherine J; Oken, Emily; Kelesidis, Theodoros; Rifas-Shiman, Sheryl L; Gillman, Matthew W (2010). "Maternal diet and cord blood leptin and adiponectin concentrations at birth". Clinical Nutrition. 29 (5): 622–6. doi:10.1016/j.clnu.2010.03.004. PMC 2916023. PMID 20363059.
  58. Tsiodras, Sotiris; Poulia, Kalliopi-Anna; Yannakoulia, Mary; Chimienti, Sonia N; Wadhwa, Sanjivini; Karchmer, Adolf W; Mantzoros, Christos S (2009). "Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy". Metabolism. 58 (6): 854–9. doi:10.1016/j.metabol.2009.02.012. PMC 2829239. PMID 19375132.
  59. Fung, T. T; Rexrode, K. M; Mantzoros, C. S; Manson, J. E; Willett, W. C; Hu, F. B (2009). "Mediterranean Diet and Incidence of and Mortality from Coronary Heart Disease and Stroke in Women". Circulation. 119 (8): 1093–100. doi:10.1161/CIRCULATIONAHA.108.816736. PMC 2724471. PMID 19221219.
  60. Yannakoulia, Mary; Yiannakouris, Nikos; Melistas, Labros; Kontogianni, Meropi D; Malagaris, Ioannis; Mantzoros, Christos S (2008). "A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women". Metabolism. 57 (6): 824–30. doi:10.1016/j.metabol.2008.01.027. PMID 18502266.
  61. Mantzoros, C. S; Williams, C. J; Manson, J. E; Meigs, J. B; Hu, F. B (2006). "Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women". The American Journal of Clinical Nutrition. 84 (2): 328–35. doi:10.1093/ajcn/84.1.328. PMID 16895879.
  62. Farr, Olivia M; Li, Chiang-Shan R; Mantzoros, Christos S (2016). "Central nervous system regulation of eating: Insights from human brain imaging". Metabolism. 65 (5): 699–713. doi:10.1016/j.metabol.2016.02.002. PMC 4834455. PMID 27085777.
  63. Farr, Olivia M; Sofopoulos, Michail; Tsoukas, Michael A; Dincer, Fadime; Thakkar, Bindiya; Sahin-Efe, Ayse; Filippaios, Andreas; Bowers, Jennifer; Srnka, Alexandra; Gavrieli, Anna; Ko, Byung-Joon; Liakou, Chrysoula; Kanyuch, Nickole; Tseleni-Balafouta, Sofia; Mantzoros, Christos S (2016). "GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: A crossover, randomised, placebo-controlled trial". Diabetologia. 59 (5): 954–65. doi:10.1007/s00125-016-3874-y. PMC 4826792. PMID 26831302.
  64. Farr, O. M; Upadhyay, J; Gavrieli, A; Camp, M; Spyrou, N; Kaye, H; Mathew, H; Vamvini, M; Koniaris, A; Kilim, H; Srnka, A; Migdal, A; Mantzoros, C. S (2016). "Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate with Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial". Diabetes. 65 (10): 2943–53. doi:10.2337/db16-0635. PMC 5033259. PMID 27385157.
  65. http://www.metabolismjournal.com/%5B%5D%5B%5D
  66. "Coherus BioSciences - A Biosimilar Therapeutics Developer".
  67. "Coherus Bio's CHS-131 shows positive effect in mid-stage MS study".
  68. "press release for Dr. Mantzoros's 2017-2018 awards".
  69. "CS Mantzoros Linked In Profile".
  70. "The American Society for Clinical Investigation". Retrieved 2019-07-03.
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