Childhood trauma

Childhood trauma is referred to in academic literature as serious adverse childhood experiences (ACEs).[1] Children may go through a range of experiences that classify as psychological trauma, these might include neglect,[2] abandonment,[2] sexual abuse, and physical abuse,[2] parent or sibling is treated violently or there is a parent with a mental illness. These events have profound psychological, physiological, and sociological impacts and can have negative, lasting effects on health and well-being. Kaiser Permanente and the Centers for Disease Control and Prevention's 1998 study on adverse childhood experiences determined that traumatic experiences during childhood are a root cause of many social, emotional, and cognitive impairments that lead to increased risk of unhealthy self-destructive behaviors,[2] risk of violence or re-victimization, chronic health conditions, low life potential and premature mortality. As the number of adverse experiences increases, the risk of problems from childhood through adulthood also rises.[3] Nearly 30 years of study following the initial study has confirmed this. Many states, health providers, and other groups now routinely screen parents and children for ACEs.

Health outcomes
Main article: Early childhood trauma
Lasting effects of Adverse Childhood Experiences

Traumatic experiences during childhood causes stress that increases an individual's allostatic load and thus affects the immune system, nervous system, and endocrine system.[4][5][6][7] Childhood trauma is often associated with adverse health outcomes including depression, hypertension, autoimmune diseases, lung cancer, and premature mortality.[4][6][4][8][9] Effects of childhood trauma on brain development includes a negative impact on emotional regulation and impairment of development of social skills.[6] Research has shown that children raised in traumatic or risky family environments tend to have excessive internalizing (e.g., social withdrawal, anxiety) or externalizing (e.g., aggressive behavior), and suicidal behavior.[6][10][11] Recent research has found that physical and sexual abuse are associated with mood and anxiety disorders in adulthood, while personality disorders and schizophrenia are linked with emotional abuse as adults.[12][13]

Psychological impact
Main article: Stress in early childhood

Childhood trauma can increase the risk of mental disorders including posttraumatic stress disorder (PTSD), attachment issues, depression, and substance abuse. Sensitive and critical stages of child development can result in altered neurological functioning, adaptive to a malevolent environment but difficult for more benign environments.

In a study done by Stefania Tognin and Maria Calem comparing healthy comparisons (HC) and individuals at clinically high risk for developing psychosis (CHR), 65.6% CHR patients and 23.1% HC experienced some level of childhood trauma. The conclusion of the study shows that there is a correlation between the effects of childhood trauma and the being at high risk for psychosis.[14]

Epigenetics

Child abuse can leave tracks, not only physically and emotionally, but also in the form of epigenetic marks on a child's genes. Although these epigenetic marks do not cause mutations in the DNA itself, the chemical modifications-including DNA methylation-change gene expression by silencing (or activating) genes. This can alter fundamental biological processes and adversely affect health outcomes throughout life.[15] A 2013 study found that people who had experienced childhood trauma had different neuropathology than people with PTSD from trauma experienced after childhood.[16] Another recent study in rhesus macaques showed that DNA methylation changes related to early-life adversity persisted into adulthood.[17]

The theoretical link between exposure to extreme stress and the development of PTSD provided the rationale for early hypotheses that PTSD-related biological alterations would be similar in direction to those observed acutely in animals exposed to stressors. When subsequent findings indicated that only a minority of trauma-exposed individuals develop PTSD, an alternative hypothesis was generated proposing that PTSD involves a failure of mechanisms involved in recovery and restitution of physiological homeostasis, possibly resulting from individualistic predisposition. Translational studies of PTSD are the use of a developmental neurobiological approach, spanning across the entire course of the illness. Symptom severity in PTSD can wax and wane over several decades. Biological alterations reflecting risk rather than pathophysiology may not account for this phenomenon. On the other hand, even putative risk factors such as glucocorticoid responsiveness and hippocampal volume show changes in response to factors such as environmental exposures, duration of illness, comorbidity, and aging. Thus, it is important to understand whether risk factors influence, or are influenced by, other parameters associated with PTSD (Yehuda, and LeDooux, 2007).[18]

In 2006, a study was published explaining that the effect of maternal PTSD symptoms related to cortisol has been shown to be associated with infant cortisol levels as early as the first year of life, and may be associated with in utero effects of maternal stress Indeed. infants of mothers who developed PTSD in response to direct exposure to the World Trade Center (WTC) attacks showed decreased salivary cortisol levels early in life, compared to infants of WTC-exposed mothers who did not develop PTSD. This effect was most apparent in infants whose mothers were exposed during their third trimester of pregnancy. Their findings suggest that mothers with a greater susceptibility for developing PTSD may produce infants who are more easily distressed by novelty than are infants of mothers who are less prone to develop PTSD. Alternatively, mothers who more readily develop PTSD may perceive and then rate their infants as having generally negative temperaments. This was not the case, however, because these mothers only rated their infants as having greater distress to novelty but not as having other negative temperamental traits. The extent to which the behavioral changes in offspring persist is an important area for future inquiry (Brand, Engel, Canfield, and Yehuda, 2006).

In this sense parental trauma exposure is associated with greater risk for post-traumatic stress disorder (PTSD) and mood and anxiety disorders in offspring since biological alterations associated with PTSD and/or other stress-related disorders have also been observed in offspring of trauma survivors who do not themselves report trauma exposure or psychiatric disorder. Animal models have demonstrated that stress exposure can result in epigenetic alterations in the next generation, and such mechanisms have been hypothesized to underpin vulnerability to symptoms in offspring of trauma survivors. Enduring behavioral responses to stress and epigenetic alterations in adult offspring have been demonstrated to be mediated by changes in gametes in utero effects, variations in early postnatal care, and/or other early life experiences that are influenced by parental exposure (Yehuda, Daskalakis, Bierer, Bader, Klengel, Holsboer, and Binder, 2015).

Survivors of war trauma or childhood maltreatment are at increased risk for trauma-spectrum disorders[19] such as post-traumatic stress disorder (PTSD). In addition, traumatic stress has been associated with alterations in the neuroendocrine and the immune system, enhancing the risk for physical diseases. Traumatic experiences might even affect psychological as well as biological parameters in the next generation, i.e. traumatic stress might have trans generational effects. So currently there is a new field trying to explain how epigenetic processes, which represent a pivotal biological mechanism for dynamic adaptation to environmental challenges, might contribute to the explanation of the long-lasting and intergenerational effects of trauma. In particular, epigenetic alterations in genes regulating the hypothalamus–pituitary–adrenal axis as well as the immune system have been observed in survivors of childhood and adult trauma.

These changes could result in enduring alterations of the stress response as well as the physical health risk. Furthermore, the effects of parental trauma could be transmitted to the next generation by parental distress and the pre- and postnatal environment, as well as by epigenetic marks transmitted via the germline. While epigenetic research has a high potential of advancing our understanding of the consequences of trauma, the findings have to be interpreted with caution, as epigenetics only represent one piece of a complex puzzle of interacting biological and environmental factors (Ramo-Fernández, Schneider, Wilker, Kolassa, 2015).

An example of this was the study led by Yehuda, Daskalakis, Bierer, Bader, Klengel, Holsboer and Binder, 2015), that studied Holocaust survivors and their offspring have methylation changes on the same site in a functional intronic region of the FKBP5 gene, a GR-binding sequence in intron 7, but in the opposite direction these results provide the first demonstration of an association of pre-conception stress effects with epigenetic changes in both exposed parents and their offspring in adult humans. Bin 3/site 6 methylation was not associated with the FKBP5 risk allele and could not be attributed to the offspring's own trauma exposure, their own psychopathology, or other examined characteristics that might independently affect methylation of this gene. Yet, it could be attributed to Holocaust exposure in the F0, with this their data support an intergenerational epigenetic priming of the physiological response to stress in offspring of highly traumatized individuals. These changes may contribute to the increased risk for psychopathology in the F1 generation. Two sites anticipated to operate similarly to regulate FKBP5 gene expression were demonstrated to have different environmental influences. The mechanism of intergenerational transmission of epigenetic effects at bin 3/site 6 is not known but does not appear to be mediated by childhood adversity, as is the case for bin 2. From a biological perspective, accommodation to multiple environmental influences at distinct and potentially redundant sites on genes central to stress regulation would facilitate maximal stress responsively and adaptation.

Future studies should focus on assessing the effects of trauma at various developmental stages, as well as potential differences in maternal and paternal effects. Additionally, the mechanism of intergenerational transmission of trauma and functional importance of site specificity remain to be explored. Early detection of such epigenetic marks may advance the development of preventive strategies to address the intergenerational sequel of exposure to trauma.

As it has been said Cytosine methylation of glucocorticoid related genes represents an epigenetic modification thought to underlie the developmental programming of hypothalamic-pituitary-adrenal (HPA) axis function. The importance of epigenetic studies offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. This is because Plasticity of the epigenome appears to constitute a molecular mechanism whereby genetic predispositions may be influenced by environmental exposures resulting in sustained alterations in gene expression and protein synthesis Epigenetic modifications of a glucocorticoid receptor (GR) gene promoter were first described in the rat as a mechanism by which variations in parent – offspring interactions influence HPA-axis and behavioural responses to stress. Maternal care regulates the methylation state of the GR exon 17 promoter in hippocampus, which in turn, regulates GR expression, the capacity for glucocorticoid negative feedback, and HPA-axis responses to stress (5, 7).

Subsequent studies in humans showed that childhood adversity associates with higher methylation of the GR exon 1F promoter (the human ortholog of the rat exon 17 promoter sequence) lower hippocampal GR expression and increased HPA-axis responses to stress. The examination of biological measures in association with PTSD symptom change following an efficacious psychotherapy trial was designed to yield a sample with a variable degree of symptom improvement, with some showing large decreases in symptom severity, and others, minimal or moderate change. An additional advantage of this approach is the ability to modify symptoms without introducing exogenousmedications that might have direct effects on the biological measures of interest. (Yehuda, Daskalakis, Desarnaud, Makotkine, Lehrner, Koch, Flory, Buxbaum, Meaney, and Bierer, 2013; Yahyavi, Zarghami, Marwah, 2014).

Epidemiologic research has clarified risk factors that increase the likelihood of PTSD after exposure to a potentially traumatic event. PTSD is an interaction between a subject, a traumatogenic factor and a social context. With each epidemiological, psychopathological and more particularly neurogenetic study, we will expand on the impact of these interactions on the therapeutic treatment of psycho-traumatized persons (Uuxéméry, 2012).

Socioeconomic costs

The social and economic costs of child abuse and neglect are difficult to calculate. Some costs are straightforward and directly related to maltreatment, such as hospital costs for medical treatment of injuries sustained as a result of physical abuse and foster care costs resulting from the removal of children when they cannot remain safely with their families. Other costs, less directly tied to the incidence of abuse, include lower academic achievement, adult criminality, and lifelong mental health problems. Both direct and indirect costs impact society and the economy.[20][21]

Transgenerational effects
Main article: Transgenerational trauma

People can pass their epigenetic marks including de-myelinated neurons to their children. The effects of trauma can be transferred from one generation of childhood trauma survivors to subsequent generations of offspring. This is known as transgenerational trauma or intergenerational trauma, and can manifest in parenting behaviors as well as epigenetically.[22][23][24] Exposure to childhood trauma, along with environmental stress, can also cause alterations in genes and gene expressions.[25][26][27] A growing body of literature suggests that children's experiences of trauma and abuse within close relationships not only jeopardize their well-being in childhood, but can also have long-lasting consequences that extend well into adulthood.[28] These long-lasting consequences can include emotion regulation issues, which can then be passed onto subsequent generations through child-parent interactions and learned behaviors.[29] (see also behavioral epigenetics, epigenetics, historical trauma, and cycle of violence)

Resilience
Main article: Psychological resilience

Exposure to maltreatment in childhood significantly predicts a variety of negative outcomes in adulthood.[30] However, not all children who are exposed to a potentially traumatic event develop subsequent struggles with mental or physical health.[31] Therefore, there are factors that reduce the impact of potentially traumatic events and protect an individual from developing mental health problems after exposure to a potentially traumatic event. These are called resiliency factors.

Research regarding children who showed adaptive development while facing adversity began in the 1970s and continues to this day.[32] Resilience is defined as “the process of, capacity for, or outcome of successful adaptation despite challenging or threatening circumstances."[33] The concept of resilience stems from research that showed experiencing positive emotions had a restorative and preventive effect on the experience of negative emotions more broadly with regards to physical and psychological wellbeing in general and more specifically with reactions to trauma.[34][35] This line of research has contributed to the development of interventions that focus on promoting resilience as opposed to focusing on deficits in an individual who has experienced a traumatic event.[32] Resilience has been found to decrease risk of suicide, depression, anxiety and other mental health struggles associated with exposure to trauma in childhood.[36][37][38][39]

When an individual who is high in resilience experiences a potentially traumatic event, their relative level of functioning does not significantly deviate from the level of functioning they exhibited prior to exposure to a potentially traumatic event.[33] Furthermore, that same individual may recover more quickly and successfully from a potentially traumatic experience than an individual who could be said to be less resilient.[33] In children, level of functioning is operationalized as the child continuing to behave in a manner that is considered developmentally appropriate for a child of that age.[32] Level of functioning is also measured by the presence of mental health disorders such as depression, anxiety, posttraumatic stress disorder, and so on.[31]

Factors that affect resilience

Factors that affect resilience include cultural factors like socioeconomic status, such that having more resources at one's disposal usually equates to more resilience to trauma.[32] Furthermore, the severity and duration of the potentially traumatic experience affect the likelihood of experiencing negative outcomes as a result of childhood trauma.[31][37] One factor that does not affect resilience is gender, with both males and females being equally sensitive to risk and protective factors.[31] Cognitive ability is also not a predictor of resilience.[31]

Attachment has been shown to be one of the most important factors to consider when it comes to evaluating the relative resilience of an individual.[31] Children with secure attachments to an adult with effective coping strategies were most likely to endure adverse childhood experiences (ACEs) in an adaptive manner.[32] Secure attachments throughout the lifespan (including in adolescence and adulthood) appear to be equally important in fostering and maintaining resilience.[31] Secure attachment to one's peers throughout adolescence is a particularly strong predictor of resilience.[31] Within the context of abuse, it is thought that these secure attachments decrease the extent to which children who are abused perceive others as being untrustworthy.[31] In other words, while some children who are abused might begin to view other people as being unsafe and unable to be trusted, children who are able to develop and maintain healthy relationships are less likely to hold these views. Children who experience trauma but also experience healthy attachment with multiple groups of people (in essence, adults, peers, romantic partners, etc.) throughout childhood, adolescence, and adulthood are particularly resilient.[31]

Personality also affects the development (or lack of development) of adult psychopathology as a result of childhood abuse.[31] Individuals who scored low in neuroticism exhibit fewer negative outcomes, such as psychopathology, criminal activity, and poor physical health, after exposure to a potentially traumatic event.[31] Furthermore, individuals with higher scores on openness to experience, conscientiousness, and extraversion have been found to be more resilient to the effects of childhood trauma.[40][41]

Enhancing resilience

One of the most common misconceptions about resilience is that individuals who show resilience are somehow special or extraordinary in some way.[32] Successful adaptation, or resilience, is quite common among children.[32] This is due in part to the naturally adaptive nature of childhood development. Therefore, resilience is enhanced by protecting against factors that might undermine a child's inborn resilience.[32] Studies suggest that resiliency can be enhanced by providing children who have been exposed to trauma with environments in which they feel safe and are able to securely attach to a healthy adult.[42] Therefore, interventions that promote strong parent-child bonds are particularly effective at buffering against the potential negative effects of trauma.[42]

Furthermore, researchers of resilience argue that successful adaptation is not merely an end result but rather a developmental process that is ongoing throughout a person's lifetime.[42] Thus, successful promotion of resilience must also be ongoing throughout a person's lifespan.

Prognosis

Trauma affects all children differently (see stress in early childhood). Some children who experience trauma develop significant and long-lasting problems, while others may have minimal symptoms and recover more quickly.[43] Studies have found that despite the broad impacts of trauma, children can and do recover, and that trauma-informed care and interventions produce better outcomes than “treatment as usual”. Trauma-informed care is defined as offering services or support in a way that addresses the special needs of people who have experienced trauma.[44]

Types

Medical trauma

Medical trauma, sometimes called "pediatric medical traumatic stress" refers to a set of psychological and physiological responses of children and their families to pain, injury, serious illness, medical procedures, and invasive or frightening treatment experiences. Medical trauma may occur as a response to a single or multiple medical events.[45]

Separation trauma

Separation trauma[46] is a disruption in an attachment relationship that disrupts neurological development and can lead to death.[47][48] Chronic separation from a caregiver can be extremely traumatic to a child.[49][50]

Treatment

The effects of childhood trauma can be mitigated through care and treatment. Early intervention has significant impact.[51][52] Trauma-informed treatment modalities treat the whole person, recognizing the impact of trauma on physical, psychological, and social health.[53]

Reducing stress hormones (cortisol, adrenaline, testosterone) is a vital early step for effective treatment of complex childhood trauma.[54]

At the present time, the evolving standard of care for the treatment of PTSD includes psychotherapy supplemented by psychopharmacology, where appropriate and used to relieve posttraumatic symptoms as well as associated symptoms of depression, anxiety, obsessive–compulsive disorder and, on occasion, psychosis, carefully applied according to the needs of the client. This is particular important because the overall cost of mental illness to the U.S. economy is staggering, with a 2008 report estimating costs over $300 billion, both the direct costs of mental health care and indirect costs including loss of income from unemployment (McCall-Hosenfield, Mukherjee, Lehman, 2014).

Despite demonstrated effectiveness of cognitive-behavioral psychotherapies for posttraumatic stress disorder (PTSD), there is limited research on the trajectory of PTSD symptom change during the course of these therapies. In addition, existent findings are mixed, making it difficult to know how individuals’ PTSD symptoms will change from week to week during psychotherapy (Schumm, Jeremiah, Kristen, Chard, 2013).

Cognitive behavioral therapy (CBT) is the psychological treatment of choice for PTSD and is recommended by best-practice treatment guidelines e.g. CBT typically involves confrontation with, and processing of, the trauma memory in a safe, gradual manner; identification and restructuring of problematic beliefs; and de-arousal skills. There is strong research evidence for use of these CBT techniques to treat PTSD in terms of magnitude of symptom reduction from pre-treatment levels, and diagnostic recovery. Associated treatment barriers include stigma, cost, geography and insufficient treatment availability (Allen, Newby, Smith and Andrews, 2015).

The treatment of CPTSD is cued to the diagnostic criteria that the seven areas of impairment described earlier: (a) alterations in the capacity to regulate emotions, (b) alterations in conscious- ness and identity, (c) alterations in self- perception, (d) alterations in perception of the perpetrator, (e) somatization, (f) alterations in perceptions of others, and (g) alterations in systems of meaning. The treatment approach that is most recommended at the present time is that of a meta-model that encourages careful sequencing of therapeutic activities and tasks, with specific initial attention to the individual's safety and ability to regulate his or her emotional state. By this reason psychopharmacology is another treatment for the related physical–psychological symptoms. A need to combine psychopharmacology and psychotherapy is usually recommended, including for CPTSD patients (Van Wesel, Alisic, Boeije, 2014).

The clinical relevance of recognizing the existence of complex PTSD in a patient is because the diagnosis is believed to merit a treatment plan that is different from that recommended by treatment guidelines for PTSD in adults (e.g., NICE, 2005). Treatment guidelines for PTSD in adults recommend trauma-focused treatment as a first line intervention for all patients with chronic PTSD. Trauma-focused treatment can be defined as treatment that focuses on "the patients' memories of their traumatic events and the personal meanings of the trauma". This consists of a first phase that focuses on safety, symptom reduction, and skills training; a second phase that focuses on processing of traumatic memories; and a third phase that focuses on social and psychological (re-) integration. Stand-alone trauma focused treatment is believed to carry a risk of psychologically overwhelming the patient and consequently of psychological de-compensation (Ter Heide, Mooren, Kleber, 2016).

A different approach is the Dialectical Behavior Therapy (DBT) which is well-established based on efficacy as well as effectiveness research and widespread acceptance by practicing clinicians, yet its primary benefits over and above community treatment by expert clinicians have been shown to be preventing self-harm and enhancing interpersonal functioning by reducing experiential avoidance and expressed anger (Ford, Courtois, 2014).

Structural and content-related features of trauma narratives of traumatic events may help explain the development of posttraumatic stress disorder (PTSD). In a sample of 35 female assault survivors, we examined the association between the structure and content of trauma narratives and PTSD and other trauma-related reactions (i.e., depression, anxiety, anger, dissociation, and guilt). When controlling for recounting style and recounting distress, narrative structure was not strongly associated with PTSD or other trauma-related reactions. In contrast, the content of the trauma narratives (more positive and negative emotion words, higher cognitive process, and less self-focus) was associated with lower symptomatology. Taken together, trauma narrative content rather than grammatical structure of the narrative may be more reflective of underlying emotional processing of the traumatic memory or lack thereof (Jaeger, Lindblom, Parker-Guilbert, Zoellner, 2014).

Another therapeutic option is the efficacy of Real Life Heroes (RLH) treatment was tested with 119 children in 7 child and family service programs, by (Kagan, James; Trinkle, LaFrenier, (2014), ranging from home-based family counseling to residential treatment. RLH is a sequential, attachment-centered treatment intervention for children with Complex PTSD that focuses on 3 primary components: affect regulation, emotionally supportive relationships, and life story integration to build resources and skills for resilience. Results included statistically significant decreases from baseline to 6 months in child behavior problems on the CBCL (Internalizing and Total Behavior), the Anger subscale of the TSCC, the UCLA PTSD Index-Parent Version (Re-experiencing, Avoidance, Hyper arousal, and Total Symptoms), and the UCLA PTSD Index-Child Version (Avoidance and Total Symptoms). Significant reductions were also found with repeated measures at 3-month assessments from baseline to 9 months on the CBCL, the UCLA Parent and Child Versions, and the PTSD subscale of the TSCC. Children receiving RLH did not have placements or psychiatric hospitalizations, a positive, but not significant trend, compared with trauma-informed "treatment as usual" provided by RLH-trained practitioners in the same programs. The study supported the efficacy of implementing trauma and resiliency-focused treatment in a wide range of child welfare programs and the importance of providing sequential attachment-centered treatment for children with symptoms of Complex PTSD.

The consensus or meta-model that is most in use in the contemporary treatment of CPTSD involves stages of treatment that are organized to address specific issues and skills (Courtois, 2004). A model consisting of three stages is widely adopted, following the recommendation made in Herman's influential and pioneering book on CPTSD, Trauma and Recovery (Herman, 1992). A model similar to this one was originally conceptualized and implemented for the treatment of chronic trauma by the French neurologist, Pierre Janet, at the end of the last century. The early stage of treatment is devoted to the development of the treatment alliance, affect regulation, education, safety, and skill-building. The middle stage, generally undertaken when the client has enough life stability and has learned adequate affect modulation and coping skills, is directed toward the processing of traumatic material in enough detail and to a degree of completion and resolution to allow the individual to function with less posttraumatic impairment. The third stage is targeted toward life consolidation and restructuring, in other words, toward a life that is less affected by the original trauma and its consequences (Courtois, 2004).

Research also covers the treatment of posttraumatic stress disorder (PTSD) among traumatized youth involved with the juvenile justice system. The first section presents the rationale for taking a family systems approach to respond to this problem and describes the ways in which family processes and parent–child relationships reciprocally affect one another in the aftermath of traumatic events. The second section outlines the key features of Functional Family Therapy (FFT) and makes the case for why this evidence-based intervention provides firm bedrock upon which to build a targeted trauma-focused adaptation. The third section of the article outlines the FFT-Trauma Focused model and describes the methods of its flexible and individualized implementation with families of traumatized delinquent youth (Kerig, Alexander, 2012).

Other option is the Narrative-Emotion Process Coding System (NEPCS) is a behavioral coding system that identifies eight client markers: Abstract Story, Empty Story, Unstoried Emotion, Inchoate Story, Same Old Story, Competing Plotlines Story, Unexpected Outcome Story, and Discovery Story. Each marker varies in the degree to which specific narrative and emotion process indicators are represented in one-minute time segments drawn from videotaped therapy sessions. As enhanced integration of narrative and emotional expression has previously been associated with recovery from complex trauma (Carpenter, Angus, Paivio, Bryntwick, 2015). On the other hand, the Attachment, Self-Regulation, and Competency (ARC) Framework is one of a handful of emerging treatment models being developed in partnership with the National Child Traumatic Stress Network (NCTSN) as an intervention for children and adolescents impacted by complex trauma. The ARC framework is a flexible, component-based intervention for treating children and adolescents who have experienced complex trauma. The ARC framework is theoretically grounded in attachment, trauma, and developmental theories and specifically addresses three core domains impacted by exposure to chronic, interpersonal trauma: attachment, self-regulation, and developmental competencies Attachment, self -regulation, competency, trauma experience integration, within those domains, the framework is organized around 10 core targets or building blocks of intervention (Arnsten, Raskind, Taylor, Connor, 2015).

Bush, Prins, Laraway, O’Brien, Ruzek, Ciulla, (2014) explored in a pilot study a non-concurrent, multiple-baseline single-case design to examine the impact of an online self-management posttraumatic stress (PTS) workshop on self-reported symptoms of PTS, depression, and functional impairment. Eleven student veterans with PTS first completed between three and five weekly baseline measures. Second, they took part in eight weekly online workshop sessions, each accompanied by symptom assessments. Third, they completed post intervention outcome measures. These researchers found statistically significant reductions in PTS from baseline across workshop sessions for four of 11 participants, and significant overall reductions in PTS between enrollment and post intervention for five participants. One participant also demonstrated significantly reduced depressive symptoms from baseline across the intervention, and two evidenced significant overall reductions from enrollment to post intervention. Three student veterans showed significantly improved general functioning across the sessions and one reported significant overall functional increase. Finally, five of six participants who completed extended measures of educational function showed significant improvements from enrollment to post intervention. Among secondary outcomes, more than 80% of those taking part said they would recommend the online PTS workshop to a colleague or fellow student with PTS issues.

This gap in services seems particularly unfortunate, in that there are a number of well-established treatments for PTSD. Cognitive behavioral therapy (CBT) for PTSD, in particular those interventions that include exposure therapy, has excellent empirical support in randomized control trials (Frueh, Anouk, Cusack, Kimble, Elhai, Knapp, 2009).

Effects on adults

As an adult feelings of anxiety, worry, shame, guilt, helplessness, hopelessness, grief, sadness and anger that started with a trauma in childhood can continue. In addition, those who endure trauma as a child are more likely to encounter anxiety, depression, suicide and self harm, PTSD, drug and alcohol misuse and relationship difficulties.[55] The effects of childhood trauma don't end with just emotional repercussions. Survivors of childhood trauma are also at higher risk of developing asthma, coronary heart disease, diabetes or having a stroke. They are also more likely to develop a "heightened stress response" which can make it difficult for them to regulate their emotions, lead to sleep difficulties, lower immune function, and increase the risk of a number of physical illnesses throughout adulthood.[55]

gollark: Yes, I'll just casually travel 10000 blocks.
gollark: Birch Forest, why?
gollark: 823 -9524
gollark: koords.
gollark: <@113673208296636420> What are your ĸøø¶ds?

References
  1. Pearce, J; Murray, C; Larkin, W (July 2019). "Childhood adversity and trauma: experiences of professionals trained to routinely enquire about childhood adversity". Heliyon. 5 (7): e01900. doi:10.1016/j.heliyon.2019.e01900. PMC 6658729. PMID 31372522.
  2. Van Der Kolk, B. A.; Perry, J. C.; Herman, J. L. (1992). "Childhood origins of self-destructive behavior". American Journal of Psychiatry. 12 (148): 1665–71. doi:10.1176/ajp.148.12.1665. PMID 1957928.
  3. "The Adverse Childhood Experiences (ACE) Study". Centers for Diesase Control. Retrieved 6 June 2017.
  4. Brown DW, Anda RF, Felitti VJ, Edwards VJ, Malarcher AM, Croft JB, Giles WH (January 2010). "Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study". BMC Public Health. 10: 20. doi:10.1186/1471-2458-10-20. PMC 2826284. PMID 20085623.
  5. Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB (February 2009). "Cumulative childhood stress and autoimmune diseases in adults". Psychosomatic Medicine. 71 (2): 243–50. doi:10.1097/PSY.0b013e3181907888. PMC 3318917. PMID 19188532.
  6. Taylor SE, Lerner JS, Sage RM, Lehman BJ, Seeman TE (December 2004). "Early environment, emotions, responses to stress, and health". Journal of Personality. 72 (6): 1365–93. CiteSeerX 10.1.1.324.5195. doi:10.1111/j.1467-6494.2004.00300.x. PMID 15509286.
  7. Motzer SA, Hertig V (March 2004). "Stress, stress response, and health". The Nursing Clinics of North America. 39 (1): 1–17. doi:10.1016/j.cnur.2003.11.001. PMID 15062724.
  8. Chapman DP, Whitfield CL, Felitti VJ, Dube SR, Edwards VJ, Anda RF (October 2004). "Adverse childhood experiences and the risk of depressive disorders in adulthood". Journal of Affective Disorders. 82 (2): 217–25. doi:10.1016/j.jad.2003.12.013. PMID 15488250.
  9. Murphy MO, Cohn DM, Loria AS (March 2017). "Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents". Neuroscience and Biobehavioral Reviews. 74 (Pt B): 453–465. doi:10.1016/j.neubiorev.2016.07.018. PMC 5250589. PMID 27450581.
  10. Aron EN, Aron A, Davies KM (February 2005). "Adult shyness: the interaction of temperamental sensitivity and an adverse childhood environment". Personality & Social Psychology Bulletin. 31 (2): 181–97. doi:10.1177/0146167204271419. PMID 15619591.
  11. Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T (2012). "The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis". PLOS Medicine. 9 (11): e1001349. doi:10.1371/journal.pmed.1001349. PMC 3507962. PMID 23209385.
  12. Sachs-Ericsson NJ, Sheffler JL, Stanley IH, Piazza JR, Preacher KJ (October 2017). "When Emotional Pain Becomes Physical: Adverse Childhood Experiences, Pain, and the Role of Mood and Anxiety Disorders". Journal of Clinical Psychology. 73 (10): 1403–1428. doi:10.1002/jclp.22444. PMC 6098699. PMID 28328011.
  13. Carr CP, Martins CM, Stingel AM, Lemgruber VB, Juruena MF (December 2013). "The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes". The Journal of Nervous and Mental Disease. 201 (12): 1007–20. doi:10.1097/NMD.0000000000000049. PMID 24284634.
  14. Tognin, Stefania; Calem, Maria (March 2017). "M122. Impact of Childhood Trauma on Educational Achievement in Young People at Clinical High Risk of Psychosis". Schizophrenia Bulletin. 43 (Suppl 1): S255. doi:10.1093/schbul/sbx022.116. ISSN 0586-7614. PMC 5475870.
  15. Zhao, Roseanne. "Child abuse leaves epigenetic marks". National Human Genome Research Institute. Archived from the original on 23 January 2019. Retrieved 12 February 2019.
  16. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ, Binder EB (May 2013). "Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder". Proceedings of the National Academy of Sciences of the United States of America. 110 (20): 8302–7. Bibcode:2013PNAS..110.8302M. doi:10.1073/pnas.1217750110. PMC 3657772. PMID 23630272.
  17. Provençal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, et al. (October 2012). "The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells". The Journal of Neuroscience. 32 (44): 15626–42. doi:10.1523/JNEUROSCI.1470-12.2012. PMC 3490439. PMID 23115197.
  18. Yehuda, Rachel; LeDoux, Joseph (2007-10-04). "Response variation following trauma: a translational neuroscience approach to understanding PTSD". Neuron. 56 (1): 19–32. doi:10.1016/j.neuron.2007.09.006. ISSN 0896-6273. PMID 17920012.
  19. Ramo-Fernández, Laura; Schneider, Anna; Wilker, Sarah; Kolassa, Iris-Tatjana (October 2015). "Epigenetic Alterations Associated with War Trauma and Childhood Maltreatment". Behavioral Sciences & the Law. 33 (5): 701–721. doi:10.1002/bsl.2200. ISSN 1099-0798. PMID 26358541.
  20. "Social and Economic Consequences of Child Abuse and Neglect". Child Welfare Information Gateway. U.S. Department of Health and Human Services. This article incorporates text from this source, which is in the public domain.
  21. "The Estimated Annual Cost of Child Abuse and Neglect". Prevent Child Abuse America.
  22. Fox M (2 May 2016). "Poor Parenting Can Be Passed From Generation to Generation". NBC News. Retrieved 2017-03-16.
  23. "Childhood trauma compromises health via diverse pathways". The Blue Knot Foundation. Archived from the original on 2017-03-22. Retrieved 2017-03-16.
  24. "Adverse Childhood Experiences (ACEs): Mental Illness of a Parent". Crow Wing Energized. Archived from the original on 2017-03-22. Retrieved 2017-03-16.
  25. Roth TL (November 2013). "Epigenetic mechanisms in the development of behavior: advances, challenges, and future promises of a new field". Development and Psychopathology. 25 (4 Pt 2): 1279–91. doi:10.1017/S0954579413000618. PMC 4080409. PMID 24342840.
  26. Feder A, Nestler EJ, Charney DS (June 2009). "Psychobiology and molecular genetics of resilience". Nature Reviews. Neuroscience. 10 (6): 446–57. doi:10.1038/nrn2649. PMC 2833107. PMID 19455174.
  27. Tyrka AR, Ridout KK, Parade SH (November 2016). "Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults". Development and Psychopathology. 28 (4pt2): 1319–1331. doi:10.1017/S0954579416000870. PMC 5330387. PMID 27691985.
  28. Kaplan SJ, Pelcovitz D, Labruna V (October 1999). "Child and adolescent abuse and neglect research: a review of the past 10 years. Part I: Physical and emotional abuse and neglect". Journal of the American Academy of Child and Adolescent Psychiatry. 38 (10): 1214–22. doi:10.1097/00004583-199910000-00009. PMID 10517053.
  29. "Maternal early-life trauma and affective parenting style: the mediating rol...: EBSCOhost". web.a.ebscohost.com. Retrieved 2017-10-04.
  30. Arnow, B. A. (2004). "Relationships between childhood maltreatment, adult health and psychiatric outcomes, and medical utilization". Journal of Clinical Psychiatry. 65: 10–15.
  31. Collishaw, Stephan; Pickles, Andrew; Messer, Julie; Rutter, Michael; Shearer, Christina; Maughan, Barbara (March 2007). "Resilience to adult psychopathology following childhood maltreatment: Evidence from a community sample". Child Abuse & Neglect. 31 (3): 211–229. doi:10.1016/j.chiabu.2007.02.004. ISSN 0145-2134. PMID 17399786.
  32. Masten, Ann S. (2001). "Ordinary magic: Resilience processes in development". American Psychologist. 56 (3): 227–238. doi:10.1037/0003-066x.56.3.227. ISSN 0003-066X.
  33. Masten, Ann S.; Best, Karin M.; Garmezy, Norman (October 1990). "Resilience and development: Contributions from the study of children who overcome adversity". Development and Psychopathology. 2 (4): 425–444. doi:10.1017/S0954579400005812. ISSN 1469-2198.
  34. "Cultivating positive emotions to optimize health and well-being". Prevention & Treatment. 3: np. 2000. CiteSeerX 10.1.1.194.4228. doi:10.1037//1522-3736.3.0001a. ISSN 1522-3736.
  35. Tugade, Michele M.; Fredrickson, Barbara L.; Feldman Barrett, Lisa (2004). "Psychological Resilience and Positive Emotional Granularity: Examining the Benefits of Positive Emotions on Coping and Health". Journal of Personality. 72 (6): 1161–1190. doi:10.1111/j.1467-6494.2004.00294.x. ISSN 0022-3506. PMC 1201429. PMID 15509280.
  36. Roy, Alec; Carli, Vladimir; Sarchiapone, Marco (2011). "Resilience mitigates the suicide risk associated with childhood trauma". Journal of Affective Disorders. 133 (3): 591–594. doi:10.1016/j.jad.2011.05.006. ISSN 0165-0327. PMID 21621850.
  37. Wingo, Aliza P.; Wrenn, Glenda; Pelletier, Tiffany; Gutman, Alisa R.; Bradley, Bekh; Ressler, Kerry J. (2010). "Moderating effects of resilience on depression in individuals with a history of childhood abuse or trauma exposure". Journal of Affective Disorders. 126 (3): 411–414. doi:10.1016/j.jad.2010.04.009. ISSN 0165-0327. PMC 3606050. PMID 20488545.
  38. Poole, Julia C.; Dobson, Keith S.; Pusch, Dennis (2017). "Childhood adversity and adult depression: The protective role of psychological resilience". Child Abuse & Neglect. 64: 89–100. doi:10.1016/j.chiabu.2016.12.012. ISSN 0145-2134. PMID 28056359.
  39. Poole, Julia C.; Dobson, Keith S.; Pusch, Dennis (2017). "Anxiety among adults with a history of childhood adversity: Psychological resilience moderates the indirect effect of emotion dysregulation". Journal of Affective Disorders. 217: 144–152. doi:10.1016/j.jad.2017.03.047. ISSN 0165-0327. PMID 28410477.
  40. Watson, David; Hubbard, Brock (1996). "Adaptational Style and Dispositional Structure: Coping in the Context of the Five-Factor Model". Journal of Personality. 64 (4): 737–774. doi:10.1111/j.1467-6494.1996.tb00943.x. ISSN 0022-3506.
  41. Campbell-Sills, Laura; Cohan, Sharon L.; Stein, Murray B. (2006). "Relationship of resilience to personality, coping, and psychiatric symptoms in young adults". Behaviour Research and Therapy. 44 (4): 585–599. doi:10.1016/j.brat.2005.05.001. ISSN 0005-7967. PMID 15998508.
  42. Yates, Tuppett M.; Egeland, Byron; Sroufe, L. Alan (2003), "Rethinking Resilience: A Developmental Process Perspective", Resilience and Vulnerability, Cambridge University Press, pp. 243–266, doi:10.1017/cbo9780511615788.012, ISBN 9780511615788
  43. "Chapter 3, Understanding the Impact of Trauma.". Trauma-Informed Care in Behavioral Health Services. Trauma-Informed Care in Behavioral Health Services (Treatment Improvement Protocol (TIP) Series. 57. Rockville (MD): Center for Substance Abuse Treatment (US). 2014.
  44. SAMHSA's Concept of Trauma and Guidance for a Trauma-Informed Approach. Rockville, MD: Substance Abuse and Mental Health Services Administration. 2014.
  45. Marsac ML, Kassam-Adams N, Delahanty DL, Widaman KF, Barakat LP (December 2014). "Posttraumatic stress following acute medical trauma in children: a proposed model of bio-psycho-social processes during the peri-trauma period". Clinical Child and Family Psychology Review. 17 (4): 399–411. doi:10.1007/s10567-014-0174-2. PMC 4319666. PMID 25217001.
  46. Thomas C (2016). "Symbolization of early separation traumas and the formation of new representations. Experiences from the analysis of a former institutionalized child". Psyche. 70 (11). doi:10.21706/ps-70-11. ISSN 0033-2623.
  47. Ward MJ, Lee SS, Lipper EG (2000). "Failure-to-thrive is associated with disorganized infant-mother attachment and unresolved maternal attachment". Infant Mental Health Journal. 21 (6): 428–442. doi:10.1002/1097-0355(200011/12)21:6<428::aid-imhj2>3.0.co;2-b.
  48. Muñoz-Hoyos A, Augustin-Morales MC, Ruíz-Cosano C, Molina-Carballo A, Fernández-García JM, Galdó-Munoz G (November 2001). "Institutional childcare and the affective deficiency syndrome: consequences on growth, nutrition and development". Early Human Development. 65 Suppl: S145–52. doi:10.1016/s0378-3782(01)00216-x. PMID 11755045.
  49. Cook A, Spinazzola J, Ford J, Lanktree C, Blaustein M, Cloitre M, DeRosa R, Hubbard R, Kagan R (2005-05-01). "Complex Trauma in Children and Adolescents". Psychiatric Annals. 35 (5): 390–398. doi:10.3928/00485713-20050501-05.
  50. Kinzie JD, Sack WH, Angell RH, Manson S, Rath B (1986). "The Psychiatric Effects of Massive Trauma on Cambodian Children: I. The Children". Journal of the American Academy of Child Psychiatry. 25 (3): 370–376. doi:10.1016/s0002-7138(09)60259-4.
  51. McPherson, Lynne; Gatwiri, Kathomi; Tucci, Joe; Mitchell, Janise; MacNamara, Noel (2018-11-01). "A paradigm shift in responding to children who have experienced trauma: The Australian treatment and care for kids program". Children and Youth Services Review. 94: 525–534. doi:10.1016/j.childyouth.2018.08.031. ISSN 0190-7409.
  52. Black, Melissa; Hitchcock, Caitlin; Bevan, Anna; Leary, Cliodhna O; Clarke, James; Elliott, Rachel; Watson, Peter; Lafortune, Louise; Rae, Sarah (2018-04-24). "The HARMONIC trial: Study protocol for a randomised controlled feasibility trial of Shaping Healthy Minds – a modular transdiagnostic intervention for mood, stress and anxiety disorders in adults". doi:10.31234/osf.io/fvc9a. Cite journal requires |journal= (help)
  53. "Trauma-Informed Care | ATTC Network". attcnetwork.org. Retrieved 2019-01-10.
  54. Gustaffsson, Per E (2017). "Diurnal cortisol levels, psychiatric symptoms and sense of coherence in abused adolescents". Nordic Journal of Psychiatry. 71 (4): 324. doi:10.1080/08039488.2017.1301704. ISSN 0803-9488.
  55. "Effects of Childhood Trauma on Adults". International Society for Traumatic Stress Studies. Retrieved February 17, 2019.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.