Charles J. Sherr

Charles J. Sherr (born 1944) is the chair of the Tumor Cell Biology Department at St. Jude Children's Research Hospital. He studies tumor suppressor genes and cell division.[2][3]

Charles J. Sherr
Born1944 (age 75–76)[1]
New York City
Alma mater
Spouse(s)Martine Roussel
Scientific career
Institutions

Sherr received his AB from Oberlin College and his MD/PhD from New York University in 1972. He did a residency in pathology at Bellevue Hospital. After one year, he joined the US Public Health Service and the National Cancer Institute in 1973, and was hired as staff in 1975. In 1977, he became head of the viral pathology section of the Division of Cancer Cause and Prevention.[4] He relocated to St Jude in 1983, and became an HHMI Investigator in 1988.[3] He has received several awards for his research in cyclin-dependent kinases and their role in cell cycle and cancer growth.[5]

He is married to Martine Roussel, a biologist, and has 3 children.[1]

Awards and honors
gollark: I think this is technically possible to implement, so bee⁻¹ you.
gollark: This is underspecified because bee² you, yes.
gollark: All numbers are two's complement because bee you.
gollark: The rest of the instruction consists of variable-width (for fun) target specifiers. The first N target specifiers in an operation are used as destinations and the remaining ones as sources. N varies per opcode. They can be of the form `000DDD` (pop/push from/to stack index DDD), `001EEE` (peek stack index EEE if source, if destination then push onto EEE if it is empty), `010FFFFFFFF` (8-bit immediate value FFFFFFFF; writes are discarded), `011GGGGGGGGGGGGGGGG` (16-bit immediate value GGGGGGGGGGGGGGGG; writes are also discarded), `100[H 31 times]` (31-bit immediate because bee you), `101IIIIIIIIIIIIIIII` (16 bits of memory location relative to the base memory address register of the stack the operation is conditional on), `110JJJJJJJJJJJJJJJJ` (16 bit memory location relative to the top value on that stack instead), `1111LLLMMM` (memory address equal to base memory address of stack LLL plus top of stack MMM), or `1110NNN` (base memory address register of stack MMM).Opcodes (numbered from 0 in order): MOV (1 source, as many destinations as can be parsed validly; the value is copied to all of them), ADD (1 destination, multiple sources), JMP (1 source), NOT (same as MOV), WR (write to output port; multiple sources, first is port number), RE (read from input port; one source for port number, multiple destinations), SUB, AND, OR, XOR, SHR, SHL (bitwise operations), MUL, ROR, ROL, NOP, MUL2 (multiplication with two outputs).
gollark: osmarksISA™️-2028 is a VLIW stack machine. Specifically, it executes a 384-bit instruction composed of 8 48-bit operations in parallel. There are 8 stacks, for safety. Each stack also has an associated base memory address register, which is used in some "addressing modes". Each stack holds 64-bit integers; popping/peeking an empty stack simply returns 0, and the stacks can hold at most 32 items. Exceeding a stack's capacity is runtime undefined behaviour. The operation encoding is: `AABBBCCCCCCCCC`:A = 2-bit conditional operation mode - 0 is "run unconditionally", 1 is "run if top value on stack is 0", 2 is "run if not 0", 3 is "run if first bit is ~~negative~~ 1".B = 3-bit index for the stack to use for the conditional.C = 9-bit opcode (for extensibility).

References
  1. "Archived copy" (PDF). Archived from the original (PDF) on 2016-07-28. Retrieved 2016-11-22.CS1 maint: archived copy as title (link)
  2. "Charles J. Sherr, MD, PhD". Stjude.org.
  3. "Charles J. Sherr, MD, PhD". Hhmi.org.
  4. "Oral History - Charles Sherr". Library.cshl.edu. Retrieved 20 May 2018.
  6. "Charles J. Sherr, MD, PhD". Aacr.org. Retrieved 20 May 2018.
  7. "Charles J. Sherr to receive Prize for Scientific Excellence in Medicine". News-medical.net. 10 October 2013. Retrieved 20 May 2018.
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