Cerebral dopamine neurotrophic factor

Cerebral dopamine neurotrophic factor also known as ARMET-like protein 1 is a protein that in humans is encoded by the CDNF gene.[5][6]

CDNF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LPN, 2W50, 4BIT
Identifiers
Aliases	CDNF, ARMETL1, cerebral dopamine neurotrophic factor
External IDs	OMIM: 611233 MGI: 3606576 HomoloGene: 27965 GeneCards: CDNF
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 14,819,245 bp[1] End 14,838,575 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 3,513,030 bp[2] End 3,526,376 bp[2]
Gene ontology Molecular function • growth factor activity Cellular component • extracellular region • extracellular • endoplasmic reticulum Biological process • neuron projection development • dopaminergic neuron differentiation • regulation of receptor activity • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	441549	227526
Ensembl	ENSG00000185267	ENSMUSG00000039496
UniProt	Q49AH0	Q8CC36
RefSeq (mRNA)	NM_001029954	NM_177647
RefSeq (protein)	NP_001025125	NP_808315
Location (UCSC)	Chr 10: 14.82 – 14.84 Mb	Chr 2: 3.51 – 3.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185267 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039496 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Cerebral dopamine neurotrophic factor".
6. Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M (Jul 2007). "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo". Nature. 448 (7149): 73–7. doi:10.1038/nature05957. PMID 17611540.

Further reading

• Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, Kim YJ (Apr 2011). "Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease". Neuroscience Letters. 493 (3): 97–101. doi:10.1016/j.neulet.2011.02.013. PMID 21320571.
• Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, O'Brien CP, Kampman KM, Oslin DW (Apr 2009). "Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence". Neuroscience Letters. 453 (3): 199–203. doi:10.1016/j.neulet.2009.02.026. PMC 2680755. PMID 19429035.
• Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A (Apr 2009). "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional". Protein Engineering, Design & Selection. 22 (4): 233–41. doi:10.1093/protein/gzn080. PMID 19258449.

External links

• Overview of all the structural information available in the PDB for UniProt: Q49AH0 (Cerebral dopamine neurotrophic factor) at the PDBe-KB.