Catharanthine

Catharanthine
Names
	Other names Methyl(5\|A)-3,4-didehydroibogamine-18-carboxylate
Identifiers
CAS Number	2468-21-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:3469;
ChemSpider	4572197;
PubChem CID	5458190;
UNII	WT0YJV846J ;
	InChI InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1 Key: CMKFQVZJOWHHDV-NQZBTDCJSA-N; InChI=1/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1 Key: CMKFQVZJOWHHDV-NQZBTDCJBW;
	SMILES CCC1=C[C@H]2C[C@]3([C@@H]1N(C2)CCc4c3[nH]c5c4cccc5)C(=O)OC;
Properties
Chemical formula	C21H24N2O2
Molar mass	336.435 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Catharanthine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus and Tabernaemontana_divaricata. Catharanthine is derived from strictosidine, but the exact mechanism by which this happens is currently unknown. Catharanthine is one of the two precursors that form vinblastine, the other being vindoline.

Uses

Modern Medicine

It showed anti-tumorogenic effect as well as inhibited cAMP phosphodiesterase activity [1]It increased the intracellular level of cAMP in neurons and thus may lead to improved neuronal activity [2]

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References

External links

Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes

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[1] ttp://medind.nic.in/iby/t08/i4/ibyt08i4p317.pdf

[2] ttps://www.thefreelibrary.com/Ethnobotany+%26+ethnopharmacology+of+Tabernaemontana+divaricata.-a0181406119