Caprin-1

Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene.[5][6][7][8][9][10] It is suggested that Caprin1 (a.k.a. RNG105) is essential for the formation of long-term memory.[11]

CAPRIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WBE, 4WBP
Identifiers
Aliases	CAPRIN1, GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, cell cycle associated protein 1
External IDs	OMIM: 601178 MGI: 1858234 HomoloGene: 4310 GeneCards: CAPRIN1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 34,051,731 bp[1] End 34,102,610 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E2 Start 103,762,941 bp[2] End 103,797,649 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding Cellular component • cytoplasmic stress granule • dendrite • P-body • integral component of plasma membrane • cell projection • membrane • cytoplasm • cytosol • synapse Biological process • cell differentiation • negative regulation of translation • positive regulation of dendrite morphogenesis • positive regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4076	53872
Ensembl	ENSG00000135387	ENSMUSG00000027184
UniProt	Q14444	Q60865
RefSeq (mRNA)	NM_005898 NM_203364	NM_001111289 NM_001111290 NM_001111291 NM_001111292 NM_016739
RefSeq (protein)	NP_005889 NP_976240	NP_001104759 NP_001104760 NP_001104761 NP_001104762 NP_058019
Location (UCSC)	Chr 11: 34.05 – 34.1 Mb	Chr 2: 103.76 – 103.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135387 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027184 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ellis JA, Luzio JP (Oct 1995). "Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". J Biol Chem. 270 (35): 20717–23. doi:10.1074/jbc.270.35.20717. PMID 7657653.
6. Wang B, David MD, Schrader JW (Sep 2005). "Absence of caprin-1 results in defects in cellular proliferation". J Immunol. 175 (7): 4274–82. doi:10.4049/jimmunol.175.7.4274. PMID 16177067.
7. Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW (Feb 2007). "Distinct Structural Features ofCaprin-1 Mediate Its Interaction with G3BP-1 and Its Induction of Phosphorylation of Eukaryotic Translation Initiation Factor 2α, Entry to Cytoplasmic Stress Granules, and Selective Interaction with a Subset of mRNAs". Mol Cell Biol. 27 (6): 2324–42. doi:10.1128/MCB.02300-06. PMC 1820512. PMID 17210633.
8. Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW (Feb 2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". J Immunol. 172 (4): 2389–400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.
9. Katsafanas GC, Moss B (Dec 2004). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". J Biol Chem. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.
10. "Entrez Gene: GPIAP1 GPI-anchored membrane protein 1".
11. https://elifesciences.org/articles/29677

Further reading

• Gessler M, Klamt B, Tsaoussidou S, et al. (1996). "The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse". Genomics. 32 (1): 169–70. doi:10.1006/geno.1996.0099. PMID 8786113.
• de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.