Calcium-binding mitochondrial carrier protein SCaMC-1

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.[5]

SLC25A24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N5X, 4ZCU, 4ZCV
Identifiers
Aliases	SLC25A24, APC1, SCAMC-1, solute carrier family 25 member 24, SCAMC1
External IDs	OMIM: 608744 MGI: 1917160 HomoloGene: 92693 GeneCards: SLC25A24
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,134,043 bp[1] End 108,200,849 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 109,123,149 bp[2] End 109,168,457 bp[2]
Gene ontology Molecular function • calcium ion binding • ATP transmembrane transporter activity • metal ion binding • ADP transmembrane transporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • membrane • mitochondrion • mitochondrial inner membrane Biological process • regulation of cell death • cellular response to calcium ion • cellular response to oxidative stress • mitochondrial transport • transmembrane transport • ATP transport • ADP transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29957	229731
Ensembl	ENSG00000085491 ENSG00000284468	ENSMUSG00000040322
UniProt	Q6NUK1	Q8BMD8
RefSeq (mRNA)	NM_013386 NM_213651	NM_172685
RefSeq (protein)	NP_037518 NP_998816	NP_766273
Location (UCSC)	Chr 1: 108.13 – 108.2 Mb	Chr 3: 109.12 – 109.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

References

1. ENSG00000284468 GRCh38: Ensembl release 89: ENSG00000085491, ENSG00000284468 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040322 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24".

Further reading

• Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F (July 2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution". The Journal of Biological Chemistry. 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600.
• del Arco A, Satrústegui J (June 2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry. 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102.
• Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981. PMID 22015608.
• Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine. 34 (2–3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187.
• Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (January 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis" (PDF). Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.

External links

• Overview of all the structural information available in the PDB for UniProt: Q6NUK1 (Human Calcium-binding mitochondrial carrier protein SCaMC-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.