CYB5R4

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.[5][6]

CYB5R4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LF5
Identifiers
Aliases	CYB5R4, NCB5OR, cb5/cb5R, dJ676J13.1, cytochrome b5 reductase 4
External IDs	OMIM: 608343 MGI: 2386848 HomoloGene: 69207 GeneCards: CYB5R4
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.2 Start 83,859,656 bp[1] End 83,967,423 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.1 Start 87,022,014 bp[2] End 87,077,774 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • NAD(P)H oxidase activity • oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor • heme binding • metal ion binding • cytochrome-b5 reductase activity, acting on NAD(P)H Cellular component • perinuclear region of cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • response to antibiotic • insulin secretion • oxidation-reduction process • detection of oxygen • generation of precursor metabolites and energy • glucose homeostasis • superoxide metabolic process • cell development • bicarbonate transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51167	266690
Ensembl	ENSG00000065615	ENSMUSG00000032872
UniProt	Q7L1T6	Q3TDX8
RefSeq (mRNA)	NM_016230	NM_024195 NM_001359962
RefSeq (protein)	NP_057314	NP_077157 NP_001346891
Location (UCSC)	Chr 6: 83.86 – 83.97 Mb	Chr 9: 87.02 – 87.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000065615 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032872 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
6. "Entrez Gene: CYB5R4 cytochrome b5 reductase 4".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu H, Larade K, Jackson TA, et al. (2004). "NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum". J. Biol. Chem. 279 (29): 30316–25. doi:10.1074/jbc.M402664200. PMC 3045664. PMID 15131110.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Andersen G, Wegner L, Rose CS, et al. (2005). "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus". Diabetes. 53 (11): 2992–7. doi:10.2337/diabetes.53.11.2992. PMC 3044473. PMID 15504981.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• Human CYB5R4 genome location and CYB5R4 gene details page in the UCSC Genome Browser.