CXXC5

CXXC-type zinc finger protein 5 is a protein that in humans is encoded by the CXXC5 gene.[5][6][7][8]

CXXC5
Identifiers
Aliases	CXXC5, CF5, RINF, WID, HSPC195, CXXC finger protein 5
External IDs	OMIM: 612752 MGI: 1914643 HomoloGene: 9517 GeneCards: CXXC5
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 139,647,299 bp[1] End 139,683,882 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2 Start 35,829,397 bp[2] End 35,861,688 bp[2]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • zinc ion binding • transcription factor binding • GO:0001948 protein binding • signal transducer activity • metal ion binding Cellular component • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51523	67393
Ensembl	ENSG00000171604	ENSMUSG00000046668
UniProt	Q7LFL8	Q91WA4
RefSeq (mRNA)	NM_016463 NM_001317199 NM_001317200 NM_001317201 NM_001317202 NM_001317203 NM_001317204 NM_001317205 NM_001317206 NM_001317207 NM_001317208 NM_001317209 NM_001317210 NM_001317211	NM_133687 NM_001357458 NM_001357459
RefSeq (protein)	NP_001304128 NP_001304129 NP_001304130 NP_001304131 NP_001304132 NP_001304133 NP_001304134 NP_001304135 NP_001304136 NP_001304137 NP_001304138 NP_001304139 NP_001304140 NP_057547	NP_598448 NP_001344387 NP_001344388
Location (UCSC)	Chr 5: 139.65 – 139.68 Mb	Chr 18: 35.83 – 35.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000171604 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046668 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. Andersson T, Sodersten E, Duckworth JK, Cascante A, Fritz N, Sacchetti P, Cervenka I, Bryja V, Hermanson O (Feb 2009). "CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells". J Biol Chem. 284 (6): 3672–81. doi:10.1074/jbc.M808119200. PMID 19001364.
7. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR (Apr 2009). "Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis". Blood. 113 (14): 3172–81. doi:10.1182/blood-2008-07-170035. PMID 19182210.
8. "Entrez Gene: CXXC5 CXXC finger 5".

External links

• Human CXXC5 genome location and CXXC5 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.