CUGBP2

CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.[5][6][7]

CELF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MY7, 2MY8, 4LJM, 4LMZ, 4TLQ
Identifiers
Aliases	CELF2, BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR, CELF-2, CUG-BP2, CUGBP, Elav-like family member 2, CUGBP Elav-like family member 2
External IDs	OMIM: 602538 MGI: 1338822 HomoloGene: 4783 GeneCards: CELF2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p14 Start 10,798,397 bp[1] End 11,336,675 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 6,539,694 bp[2] End 7,509,563 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • RNA binding • pre-mRNA binding • mRNA binding Cellular component • cytoplasm • cell nucleus • ribonucleoprotein Biological process • mRNA processing • RNA processing • regulation of heart contraction • mRNA splice site selection • regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10659	14007
Ensembl	ENSG00000048740	ENSMUSG00000002107
UniProt	O95319	Q9Z0H4
RefSeq (mRNA)	NM_001025076 NM_001025077 NM_001083591 NM_006561 NM_001326317 NM_001326318 NM_001326319 NM_001326320 NM_001326321 NM_001326323 NM_001326324 NM_001326325 NM_001326326 NM_001326327 NM_001326328 NM_001326329 NM_001326330 NM_001326331 NM_001326332 NM_001326333 NM_001326334 NM_001326335 NM_001326336 NM_001326337 NM_001326338 NM_001326339 NM_001326340 NM_001326341 NM_001326342 NM_001326343 NM_001326344 NM_001326345 NM_001326346 NM_001326347 NM_001326348 NM_001326349	NM_001110228 NM_001110229 NM_001110230 NM_001110231 NM_001110232 NM_001160292 NM_001160293 NM_010160 NM_183219 NM_001310447 NM_001347094
RefSeq (protein)	NP_001020247 NP_001020248 NP_001077060 NP_001313246 NP_001313247 NP_001313248 NP_001313249 NP_001313250 NP_001313252 NP_001313253 NP_001313254 NP_001313255 NP_001313256 NP_001313257 NP_001313258 NP_001313259 NP_001313260 NP_001313261 NP_001313262 NP_001313263 NP_001313264 NP_001313265 NP_001313266 NP_001313267 NP_001313268 NP_001313269 NP_001313270 NP_001313271 NP_001313272 NP_001313273 NP_001313274 NP_001313275 NP_001313276 NP_001313277 NP_001313278 NP_006552	NP_001103698 NP_001103699 NP_001103700 NP_001103701 NP_001103702 NP_001153764 NP_001153765 NP_001297376 NP_001334023 NP_034290
Location (UCSC)	Chr 10: 10.8 – 11.34 Mb	Chr 2: 6.54 – 7.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

CUGBP2 has been shown to interact with A1CF.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000048740 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002107 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.
6. Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.
7. "Entrez Gene: CELF2 CUGBP, Elav-like family member 2".
8. Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. United States. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.

External links

• Human CELF2 genome location and CELF2 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein". Gene. 237 (1): 135–42. doi:10.1016/S0378-1119(99)00312-1. PMID 10524244.
• Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
• Ladd AN, Charlet N, Cooper TA (2001). "The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
• Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768.
• Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
• Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2". Mol. Cell. 11 (1): 113–26. doi:10.1016/S1097-2765(03)00012-1. PMID 12535526.
• Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
• Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury". Ann. N. Y. Acad. Sci. 1010: 504–9. Bibcode:2003NYASA1010..504M. doi:10.1196/annals.1299.093. PMID 15033780.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. Bibcode:2004PNAS..10113873M. doi:10.1073/pnas.0406066101. PMC 518846. PMID 15358864.
• Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700.