CTDSP2

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.[5][6][7]

CTDSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q5E
Identifiers
Aliases	CTDSP2, OS4, PSR2, SCP2, CTD small phosphatase 2
External IDs	OMIM: 608711 MGI: 1098748 HomoloGene: 128791 GeneCards: CTDSP2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,819,927 bp[1] End 57,846,729 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.35 cM Start 126,978,717 bp[2] End 126,999,975 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • CTD phosphatase activity • phosphatase activity • GO:0001948 protein binding • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding Cellular component • cell nucleus • nucleoplasm Biological process • negative regulation of G1/S transition of mitotic cell cycle • negative regulation of protein phosphorylation • protein dephosphorylation • IRE1-mediated unfolded protein response • regulation of transcription from RNA polymerase II promoter • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10106	52468
Ensembl	ENSG00000175215	ENSMUSG00000078429
UniProt	O14595	Q8BX07
RefSeq (mRNA)	NM_005730	NM_001113470 NM_146012
RefSeq (protein)	NP_005721 NP_005721.3	NP_001106941 NP_666124
Location (UCSC)	Chr 12: 57.82 – 57.85 Mb	Chr 10: 126.98 – 127 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CTDSP2 has been shown to interact with SNAI1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175215 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078429 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su YA, Lee MM, Hutter CM, Meltzer PS (September 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene. 15 (11): 1289–94. doi:10.1038/sj.onc.1201294. PMID 9315096.
6. Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
7. "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
8. Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading

• Su YA, Trent JM, Guan XY, Meltzer PS (September 1994). "Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection". Proceedings of the National Academy of Sciences of the United States of America. 91 (19): 9121–5. Bibcode:1994PNAS...91.9121S. doi:10.1073/pnas.91.19.9121. PMC 44759. PMID 8090779.
• Beutler E, Gelbart T, West C, Kuhl W, Lee P (1996). "A strategy for cloning the hereditary hemochromatosis gene". Blood Cells, Molecules & Diseases. 21 (3): 207–16. doi:10.1006/bcmd.1995.0024. PMID 8673473.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Thompson J, Lepikhova T, Teixido-Travesa N, Whitehead MA, Palvimo JJ, Jänne OA (June 2006). "Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription". The EMBO Journal. 25 (12): 2757–67. doi:10.1038/sj.emboj.7601161. PMC 1500849. PMID 16724108.

External links

• CTDSP2 human gene location in the UCSC Genome Browser.
• CTDSP2 human gene details in the UCSC Genome Browser.
• Human SCP2 genome location and SCP2 gene details page in the UCSC Genome Browser.