CTBS

Di-N-acetylchitobiase is an enzyme that in humans is encoded by the CTBS gene.[5][6][7]

This article is about an enzyme. For Comprehensive Tests of Basic Skills, see CTB/McGraw-Hill.

CTBS
Identifiers
Aliases	CTBS, CTB, chitobiase
External IDs	OMIM: 600873 MGI: 1921495 HomoloGene: 3231 GeneCards: CTBS
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,549,611 bp[1] End 84,574,480 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 146,449,795 bp[2] End 146,465,849 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • hydrolase activity, acting on glycosyl bonds • chitinase activity • chitin binding Cellular component • lysosome • extracellular exosome • extracellular Biological process • oligosaccharide catabolic process • metabolism • chitin catabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1486	74245
Ensembl	ENSG00000117151	ENSMUSG00000028189
UniProt	Q01459	Q8R242
RefSeq (mRNA)	NM_004388	NM_001293672 NM_028836
RefSeq (protein)	NP_004379	NP_001280601 NP_083112
Location (UCSC)	Chr 1: 84.55 – 84.57 Mb	Chr 3: 146.45 – 146.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000117151 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028189 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fisher KJ, Aronson NN Jr (Apr 1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol Cell Biol. 12 (4): 1585–91. PMC 369601. PMID 1549114.
6. Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925.
7. "Entrez Gene: CTBS chitobiase, di-N-acetyl-".

External links

• Human CTBS genome location and CTBS gene details page in the UCSC Genome Browser.

Further reading

• Aronson NN, Halloran BA (2006). "Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase". Biosci. Biotechnol. Biochem. 70 (6): 1537–41. doi:10.1271/bbb.60183. PMID 16794344.
• Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hutchinson T, Dwivedi K, Rastogi A, et al. (2002). "N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor". Asian J. Androl. 4 (1): 27–33. PMID 11907625.
• Liu B, Ahmad W, Aronson NN (1999). "Structure of the human gene for lysosomal di-N-acetylchitobiase". Glycobiology. 9 (6): 589–93. doi:10.1093/glycob/9.6.589. PMID 10336991.
• Aronson NN, Backes M, Kuranda MJ (1989). "Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins". Arch. Biochem. Biophys. 272 (2): 290–300. doi:10.1016/0003-9861(89)90222-1. PMID 2751306.
• Fisher KJ, Aronson NN (1992). "Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase". J. Biol. Chem. 267 (27): 19607–16. PMID 1527079.