CSMD1

CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the CSMD1 gene.[5]

CSMD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EHF
Identifiers
Aliases	CSMD1, PPP1R24, CUB and Sushi multiple domains 1
External IDs	OMIM: 608397 MGI: 2137383 HomoloGene: 69536 GeneCards: CSMD1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.2 Start 2,935,353 bp[1] End 4,994,972 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1-A1.3 Start 15,892,537 bp[2] End 17,535,586 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64478	94109
Ensembl	ENSG00000183117	ENSMUSG00000060924
UniProt	Q96PZ7	Q923L3
RefSeq (mRNA)	NM_033225	NM_053171
RefSeq (protein)	NP_150094	NP_444401
Location (UCSC)	Chr 8: 2.94 – 4.99 Mb	Chr 8: 15.89 – 17.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Structure

CSMD1 contains 14 N-terminal CUB domains that are separated from each other by a Sushi domains followed by an additional 15 tandem Sushi domain segment.[6]

Function

Based on analogy to other proteins that contain Sushi domains, it is believed that the gene product of CSMD1 functions as a Complement control protein.[6]

Clinical significance

It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively.[7] CSMD1 protein expression was found to be reduced in patients with invasive breast cancer.[8] Functional studies showed that CSMD1 reduction causes cells to transform to a cancer form by increasing their ability to divide, migrate and invade. In a three dimensional model of breast ducts, reduced CSMD1 expression failed breast duct formation.[9]

Certain CSMD1 genetic variants have been found to show an association with risk of developing schizophrenia, consistent with emerging evidence that some forms of schizophrenia may result from dysregulated complement activation in the central nervous system resulting in excessive synaptic pruning[10].

References

1. GRCh38: Ensembl release 89: ENSG00000183117 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060924 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CSMD1 CUB and Sushi multiple domains 1".
6. Kraus DM, Elliott GS, Chute H, Horan T, Pfenninger KH, Sanford SD, Foster S, Scully S, Welcher AA, Holers VM (April 2006). "CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues". Journal of Immunology. 176 (7): 4419–30. doi:10.4049/jimmunol.176.7.4419. PMID 16547280.
7. • Toomes C, Jackson A, Maguire K, Wood J, Gollin S, Ishwad C, Paterson I, Prime S, Parkinson K, Bell S, Woods G, Markham A, Oliver R, Woodward R, Sloan P, Dixon M, Read A, Thakker N (June 2003). "The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis". Genes, Chromosomes & Cancer. 37 (2): 132–40. doi:10.1002/gcc.10191. PMID 12696061.
8. Escudero-Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, Orimo A, Jiang WG, Pietras K, Blom AM (November 2016). "Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer". Oncotarget. 7 (47): 76920–76933. doi:10.18632/oncotarget.12729. PMC 5363559. PMID 27764775.
9. Kamal M, Holliday DL, Morrison EE, Speirs V, Toomes C, Bell SM (July 2017). "Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion". Oncology Reports. 38 (1): 283–292. doi:10.3892/or.2017.5656. PMID 28534981.
10. Baum, Matthew L. (2018-09-16). "The Schizophrenia-Associated Gene, CSMD1, Encodes a Brain-Specific Complement Inhibitor". Cite journal requires |journal= (help)

External links

• Human CSMD1 genome location and CSMD1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q96PZ7 (CUB and sushi domain-containing protein 1) at the PDBe-KB.

Further reading

• Kamal M, Shaaban AM, Zhang L, Walker C, Gray S, Thakker N, Toomes C, Speirs V, Bell SM (June 2010). "Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma" (PDF). Breast Cancer Research and Treatment. 121 (3): 555–63. doi:10.1007/s10549-009-0500-4. PMID 19669408.
• Smith DI, Zhu Y, McAvoy S, Kuhn R (January 2006). "Common fragile sites, extremely large genes, neural development and cancer". Cancer Letters. 232 (1): 48–57. doi:10.1016/j.canlet.2005.06.049. PMID 16221525.
• Sun PC, Uppaluri R, Schmidt AP, Pashia ME, Quant EC, Sunwoo JB, Gollin SM, Scholnick SB (July 2001). "Transcript map of the 8p23 putative tumor suppressor region". Genomics. 75 (1–3): 17–25. doi:10.1006/geno.2001.6587. PMID 11472063.
• Nagase T, Kikuno R, Ohara O (August 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Henshall SM, Afar DE, Hiller J, Horvath LG, Quinn DI, Rasiah KK, Gish K, Willhite D, Kench JG, Gardiner-Garden M, Stricker PD, Scher HI, Grygiel JJ, Agus DB, Mack DH, Sutherland RL (July 2003). "Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse". Cancer Research. 63 (14): 4196–203. PMID 12874026.
• Lau WL, Scholnick SB (September 2003). "Identification of two new members of the CSMD gene family". Genomics. 82 (3): 412–5. doi:10.1016/S0888-7543(03)00149-6. PMID 12906867.
• Scholnick SB, Richter TM (November 2003). "The role of CSMD1 in head and neck carcinogenesis". Genes, Chromosomes & Cancer. 38 (3): 281–3. doi:10.1002/gcc.10279. PMID 14506705.
• Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M (December 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
• Paris PL, Andaya A, Fridlyand J, Jain AN, Weinberg V, Kowbel D, Brebner JH, Simko J, Watson JE, Volik S, Albertson DG, Pinkel D, Alers JC, van der Kwast TH, Vissers KJ, Schroder FH, Wildhagen MF, Febbo PG, Chinnaiyan AM, Pienta KJ, Carroll PR, Rubin MA, Collins C, van Dekken H (July 2004). "Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors". Human Molecular Genetics. 13 (13): 1303–13. doi:10.1093/hmg/ddh155. PMID 15138198.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Richter TM, Tong BD, Scholnick SB (September 2005). "Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines". Cancer Cell International. 5 (1): 29. doi:10.1186/1475-2867-5-29. PMC 1239921. PMID 16153303.
• Blaveri E, Brewer JL, Roydasgupta R, Fridlyand J, DeVries S, Koppie T, Pejavar S, Mehta K, Carroll P, Simko JP, Waldman FM (October 2005). "Bladder cancer stage and outcome by array-based comparative genomic hybridization". Clinical Cancer Research. 11 (19 Pt 1): 7012–22. doi:10.1158/1078-0432.CCR-05-0177. PMID 16203795.