Complement receptor of the immunoglobulin family
Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells.[1] It is a critical receptor for the phagocytosis of opsonised particles in the blood. It recognizes iC3b (inactivated C3b) deposited on microbial surfaces.
| V-set and immunoglobulin domain containing 4 | |
|---|---|
| Identifiers | |
| Symbol | VSIG4 |
| NCBI gene | 11326 |
| HGNC | 17032 |
| OMIM | 300353 |
| RefSeq | NM_007268 |
| UniProt | Q9Y279 |
| Other data | |
| Locus | Chr. X q12-q13.3 |
See also
References
- Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.