CRISP3

Cysteine-rich secretory protein 3 is a cysteine-rich secretory protein that in humans is encoded by the CRISP3 gene.[3][4][5]

CRISP3
Identifiers
Aliases	CRISP3, Aeg2, CRISP-3, CRS3, SGP28, dJ442L6.3, cysteine rich secretory protein 3
External IDs	OMIM: 618062 HomoloGene: 136801 GeneCards: CRISP3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.3 Start 49,727,384 bp[1] End 49,744,437 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • molecular function Cellular component • proteinaceous extracellular matrix • specific granule • extracellular exosome • extracellular region • extracellular • specific granule lumen • tertiary granule lumen • extracellular matrix • membrane • integral component of membrane Biological process • defense response • innate immune system • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10321	n/a
Ensembl	ENSG00000096006	n/a
UniProt	P54108	n/a
RefSeq (mRNA)	NM_006061 NM_001190986 NM_001368123	n/a
RefSeq (protein)	NP_001177915 NP_006052 NP_001355052	n/a
Location (UCSC)	Chr 6: 49.73 – 49.74 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000096006 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Kratzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD (Aug 1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3". Eur J Biochem. 236 (3): 827–36. doi:10.1111/j.1432-1033.1996.t01-1-00827.x. PMID 8665901.
4. Udby L, Calafat J, Sorensen OE, Borregaard N, Kjeldsen L (Sep 2002). "Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils". J Leukoc Biol. 72 (3): 462–9. PMID 12223513.
5. "Entrez Gene: CRISP3 cysteine-rich secretory protein 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kjeldsen L, Cowland JB, Johnsen AH, Borregaard N (1996). "SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein". FEBS Lett. 380 (3): 246–50. doi:10.1016/0014-5793(96)00030-0. PMID 8601434.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cowland JB, Borregaard N (2000). "The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules". J. Leukoc. Biol. 66 (6): 989–95. doi:10.1002/jlb.66.6.989. PMID 10614782.
• Friess H, Ding J, Kleeff J, et al. (2002). "Identification of disease-specific genes in chronic pancreatitis using DNA array technology". Ann. Surg. 234 (6): 769–78, discussion 778–9. doi:10.1097/00000658-200112000-00008. PMC 1422136. PMID 11729383.
• Udby L, Cowland JB, Johnsen AH, et al. (2002). "An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in human neutrophils, plasma, and exocrine secretions". J. Immunol. Methods. 263 (1–2): 43–55. doi:10.1016/S0022-1759(02)00033-9. PMID 12009203.
• Kosari F, Asmann YW, Cheville JC, Vasmatzis G (2003). "Cysteine-rich secretory protein-3: a potential biomarker for prostate cancer". Cancer Epidemiol. Biomarkers Prev. 11 (11): 1419–26. PMID 12433721.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liao Q, Kleeff J, Xiao Y, et al. (2003). "Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis". Histol. Histopathol. 18 (2): 425–33. PMID 12647793.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Udby L, Sørensen OE, Pass J, et al. (2004). "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma". Biochemistry. 43 (40): 12877–86. doi:10.1021/bi048823e. PMID 15461460.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Udby L, Bjartell A, Malm J, et al. (2005). "Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract". J. Androl. 26 (3): 333–42. doi:10.2164/jandrol.04132. PMID 15867000.
• Udby L, Lundwall A, Johnsen AH, et al. (2005). "beta-Microseminoprotein binds CRISP-3 in human seminal plasma". Biochem. Biophys. Res. Commun. 333 (2): 555–61. doi:10.1016/j.bbrc.2005.05.139. PMC 1939934. PMID 15950934.
• Bjartell A, Johansson R, Björk T, et al. (2006). "Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland". Prostate. 66 (6): 591–603. doi:10.1002/pros.20342. PMID 16388501.
• Bjartell AS, Al-Ahmadie H, Serio AM, et al. (2007). "Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy". Clin. Cancer Res. 13 (14): 4130–8. doi:10.1158/1078-0432.CCR-06-3031. PMC 2660867. PMID 17634540.
• Laine M, Porola P, Udby L, et al. (2007). "Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome". Arthritis Rheum. 56 (8): 2575–84. doi:10.1002/art.22828. PMID 17665393.

External links

• CRISP3 human gene location in the UCSC Genome Browser.
• CRISP3 human gene details in the UCSC Genome Browser.