CRIP1

Cysteine-rich protein 1 is a protein that in humans is encoded by the CRIP1 gene.[5][6]

CRIP1
Identifiers
Aliases	CRIP1, CRHP, CRIP, CRP-1, CRP1, cysteine rich protein 1
External IDs	OMIM: 123875 MGI: 88501 HomoloGene: 37465 GeneCards: CRIP1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 105,486,317 bp[1] End 105,488,947 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 61.59 cM Start 113,146,316 bp[2] End 113,153,879 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptide binding • DNA binding, bending • metal ion binding • AT DNA binding • zinc ion binding Cellular component • cytoplasm Biological process • regulation of gene expression • prostate gland stromal morphogenesis • cellular response to antibiotic • heart development • response to zinc ion • cellular proliferation • cellular response to UV-B • response to organic substance • immune response • intrinsic apoptotic signaling pathway in response to DNA damage Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1396	12925
Ensembl	ENSG00000213145	ENSMUSG00000006360
UniProt	P50238	P63254
RefSeq (mRNA)	NM_001311	NM_007763
RefSeq (protein)	NP_001302	NP_031789
Location (UCSC)	Chr 14: 105.49 – 105.49 Mb	Chr 12: 113.15 – 113.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000213145 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006360 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM (Apr 1998). "Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23". Genomics. 47 (3): 419–422. doi:10.1006/geno.1997.5134. PMID 9480758.
6. "Entrez Gene: CRIP1 cysteine-rich protein 1 (intestinal)".

External links

• Human CRIP1 genome location and CRIP1 gene details page in the UCSC Genome Browser.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Khoo C, Blanchard RK, Sullivan VK, Cousins RJ (1997). "Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells". Protein Expr. Purif. 9 (3): 379–387. doi:10.1006/prep.1996.0709. PMID 9126610.
• Khoo C, Cousins RJ (1994). "Purification and properties of rat cysteine-rich intestinal protein". Biochem. J. 299 (2): 445–50. PMC 1138292. PMID 8172605.
• Tsui SK, Yam NY, Lee CY, Waye MM (1995). "Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart". Biochem. Biophys. Res. Commun. 205 (1): 497–505. doi:10.1006/bbrc.1994.2693. PMID 7999070.
• Hempe JM, Cousins RJ (1991). "Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9671–9674. doi:10.1073/pnas.88.21.9671. PMC 52780. PMID 1946385.