Collectin-10

COLEC10
Identifiers
Aliases	COLEC10, CLL1, CL-34, collectin subfamily member 10, 3MC3
External IDs	OMIM: 607620 MGI: 3606482 HomoloGene: 31381 GeneCards: COLEC10
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	119,108,455 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	54,466,358 bp[2]
Gene ontology
Molecular function	• mannose binding; • carbohydrate binding; • serine-type endopeptidase activity; • chemoattractant activity; • monosaccharide binding;
Cellular component	• collagen; • extracellular region; • extracellular; • cytoplasm; • Golgi apparatus;
Biological process	• complement activation; • proteolysis; • complement activation, lectin pathway; • positive chemotaxis; • cranial skeletal system development; • developmental process;
	Sources:Amigo / QuickGO
Orthologs
	10584
	239447
	ENSG00000184374
	ENSMUSG00000038591
	Q9Y6Z7
	Q8CF98
	NM_006438; NM_001324095
	NM_173422
	NP_001311024; NP_006429
	NP_775598
	Wikidata
View/Edit Human	View/Edit Mouse

Collectin-10, also known as collectin liver 1, is a collectin protein that in humans is encoded by the COLEC10 gene. Its structure is similar to mannan-binding lectin (MBL).[5]

Collectin liver 1 (CL-L1) show very similar carbohydrate selectivity as MBL. Two other discovered collectins include collectin placenta 1 (CL-P1) and collectin kidney 1 (CL-K1). CL-L1's location found to be on chromosome 8 q23-24.1. Research concluded CL-L1 to be a serum protein.[6]

References

GRCh38: Ensembl release 89: ENSG00000184374 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038591 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H (March 2015). "Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure". Liver International. 35 (3): 756–63. doi:10.1111/liv.12682. PMC 4329085. PMID 25203057.
Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC (August 2013). "Investigations on collectin liver 1". The Journal of Biological Chemistry. 288 (32): 23407–20. doi:10.1074/jbc.M113.492603. PMC 3743509. PMID 23814060.

External links

collectin+liver+1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184374 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038591 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H (March 2015). "Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure". Liver International. 35 (3): 756–63. doi:10.1111/liv.12682. PMC 4329085. PMID 25203057.

[6] Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC (August 2013). "Investigations on collectin liver 1". The Journal of Biological Chemistry. 288 (32): 23407–20. doi:10.1074/jbc.M113.492603. PMC 3743509. PMID 23814060.