COG5

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.[5][6][7]

COG5
Identifiers
AliasesCOG5, CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
External IDsOMIM: 606821 MGI: 2145130 HomoloGene: 42221 GeneCards: COG5
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.3Start107,201,555 bp[1]
End107,564,514 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10466

238123

Ensembl

ENSG00000164597
ENSG00000284369

ENSMUSG00000035933

UniProt

Q9UP83

Q8C0L8

RefSeq (mRNA)

NM_001161520
NM_006348
NM_181733

NM_001163126

RefSeq (protein)

NP_001156598

Location (UCSC)Chr 7: 107.2 – 107.56 MbChr 12: 31.65 – 31.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM][7]

Interactions

COG5 has been shown to interact with COG7[8] and COG4.[8]

References

  1. ENSG00000284369 GRCh38: Ensembl release 89: ENSG00000164597, ENSG00000284369 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035933 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport". J Biol Chem. 273 (45): 29565–76. doi:10.1074/jbc.273.45.29565. PMID 9792665.
  6. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  7. "Entrez Gene: COG5 component of oligomeric golgi complex 5".
  8. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

Further reading


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