COG3

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[5][6]

COG3
Identifiers
Aliases	COG3, SEC34, component of oligomeric golgi complex 3
External IDs	OMIM: 606975 MGI: 2450151 HomoloGene: 5854 GeneCards: COG3
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.13 Start 45,464,898 bp[1] End 45,536,701 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 75,702,350 bp[2] End 75,754,558 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Golgi membrane • cis-Golgi network • membrane • Golgi apparatus • Golgi cisterna membrane • Golgi transport complex • trans-Golgi network membrane • cytosol • cell membrane Biological process • protein glycosylation • intracellular protein transport • protein stabilization • intra-Golgi vesicle-mediated transport • ER to Golgi vesicle-mediated transport • protein transport • Golgi organization • protein localization to organelle • retrograde vesicle-mediated transport, Golgi to ER Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83548	338337
Ensembl	ENSG00000136152	ENSMUSG00000034893
UniProt	Q96JB2	Q8CI04
RefSeq (mRNA)	NM_001204476 NM_031431	NM_177381
RefSeq (protein)	NP_113619	n/a
Location (UCSC)	Chr 13: 45.46 – 45.54 Mb	Chr 14: 75.7 – 75.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[6]

Interactions

COG3 has been shown to interact with COG2[7] and COG1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136152 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034893 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
6. "Entrez Gene: COG3 component of oligomeric golgi complex 3".
7. Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.

External links

• Human COG3 genome location and COG3 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S (October 1999). "High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking". Molecular Biology of the Cell. 10 (10): 3317–29. doi:10.1091/mbc.10.10.3317. PMC 25597. PMID 10512869.
• VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG (November 1999). "Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p". The Journal of Cell Biology. 147 (4): 729–42. doi:10.1083/jcb.147.4.729. PMC 2156162. PMID 10562277.
• Suvorova ES, Kurten RC, Lupashin VV (June 2001). "Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery". The Journal of Biological Chemistry. 276 (25): 22810–8. doi:10.1074/jbc.M011624200. PMID 11292827.
• Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Loh E, Hong W (June 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". The Journal of Biological Chemistry. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.