COASY

Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[5][6][7]

COASY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F6R
Identifiers
Aliases	COASY, DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2, Coenzyme A synthase, PCH12
External IDs	OMIM: 609855 MGI: 1918993 HomoloGene: 11889 GeneCards: COASY
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,561,467 bp[1] End 42,566,277 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,082,565 bp[2] End 101,086,619 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleotidyltransferase activity • kinase activity • GO:0001948 protein binding • catalytic activity • ATP binding • pantetheine-phosphate adenylyltransferase activity • dephospho-CoA kinase activity Cellular component • mitochondrial outer membrane • mitochondrial matrix • mitochondrion • extracellular exosome • cytoplasm • nucleoplasm • cytosol Biological process • phosphorylation • biosynthetic process • coenzyme A biosynthetic process • metabolism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80347	71743
Ensembl	ENSG00000068120	ENSMUSG00000001755
UniProt	Q13057	Q9DBL7
RefSeq (mRNA)	NM_001042529 NM_001042530 NM_001042531 NM_001042532 NM_025233	NM_027896 NM_001305982
RefSeq (protein)	NP_001035994 NP_001035997 NP_079509	NP_001292911
Location (UCSC)	Chr 17: 42.56 – 42.57 Mb	Chr 11: 101.08 – 101.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

COASY has been shown to interact with P70-S6 Kinase 1.[8] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000068120 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001755 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crécy-Lagard V, Osterman A (June 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". The Journal of Biological Chemistry. 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312.
6. Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (June 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". The Journal of Biological Chemistry. 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892.
7. "Entrez Gene: COASY Coenzyme A synthase".
8. Nemazanyy I, Panasyuk G, Zhyvoloup A, Panayotou G, Gout IT, Filonenko V (December 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Letters. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845.
9. Breus O, Panasyuk G, Gout IT, Filonenko V, Nemazanyy I (August 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway". Biochemical and Biophysical Research Communications. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007.

External links

• Human COASY genome location and COASY gene details page in the UCSC Genome Browser.
• Human PPAT genome location and PPAT gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Montagna M, Serova O, Sylla BS, Feunteun J, Lenoir GM (November 1995). "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase". Human Genetics. 96 (5): 532–8. doi:10.1007/bf00197407. PMID 8529999.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Aghajanian S, Worrall DM (July 2002). "Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)". The Biochemical Journal. 365 (Pt 1): 13–8. doi:10.1042/BJ20020569. PMC 1222654. PMID 11994049.
• Zhyvoloup A, Nemazanyy I, Panasyuk G, Valovka T, Fenton T, Rebholz H, Wang ML, Foxon R, Lyzogubov V, Usenko V, Kyyamova R, Gorbenko O, Matsuka G, Filonenko V, Gout IT (December 2003). "Subcellular localization and regulation of coenzyme A synthase" (PDF). The Journal of Biological Chemistry. 278 (50): 50316–21. doi:10.1074/jbc.M307763200. PMID 14514684.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Nemazanyy I, Panasyuk G, Zhyvoloup A, Panayotou G, Gout IT, Filonenko V (December 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Letters. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Nemazanyy I, Panasyuk G, Breus O, Zhyvoloup A, Filonenko V, Gout IT (March 2006). "Identification of a novel CoA synthase isoform, which is primarily expressed in the brain". Biochemical and Biophysical Research Communications. 341 (4): 995–1000. doi:10.1016/j.bbrc.2006.01.051. PMID 16460672.