CNOT6L

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.[5] It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

CNOT6L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NGN, 3NGO, 3NGQ, 5DV2
Identifiers
Aliases	CNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like
External IDs	OMIM: 618069 MGI: 2443154 HomoloGene: 100830 GeneCards: CNOT6L
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 77,713,387 bp[1] End 77,819,615 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E3 Start 96,070,333 bp[2] End 96,164,171 bp[2]
Gene ontology Molecular function • poly(A)-specific ribonuclease activity • metal ion binding • GO:0001948 protein binding • nuclease activity • exonuclease activity • hydrolase activity • 3'-5'-exoribonuclease activity Cellular component • cytoplasm • CCR4-NOT complex • cell nucleus • cytosol Biological process • nuclear-transcribed mRNA poly(A) tail shortening • regulation of transcription, DNA-templated • RNA phosphodiester bond hydrolysis, exonucleolytic • mRNA processing • transcription, DNA-templated • positive regulation of cytoplasmic mRNA processing body assembly • mRNA destabilization • positive regulation of cell proliferation • gene silencing by RNA • regulation of translation • nucleic acid phosphodiester bond hydrolysis • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246175	231464
Ensembl	ENSG00000138767	ENSMUSG00000034724
UniProt	Q96LI5	Q8VEG6
RefSeq (mRNA)	NM_001286790 NM_144571 NM_001365006 NM_001365007	NM_001285511 NM_001285514 NM_144910 NM_178854
RefSeq (protein)	NP_001273719 NP_653172 NP_001351935 NP_001351936	NP_001272440 NP_001272443 NP_659159 NP_849185
Location (UCSC)	Chr 4: 77.71 – 77.82 Mb	Chr 5: 96.07 – 96.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000138767 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034724 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

Further reading

• Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T (July 2007). "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth". Mol. Cell. Biol. 27 (13): 4980–90. doi:10.1128/MCB.02304-06. PMC 1951489. PMID 17452450.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z (August 2010). "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity". EMBO J. 29 (15): 2566–76. doi:10.1038/emboj.2010.152. PMC 2928688. PMID 20628353.
• Naylor MG, Weiss ST, Lange C (September 2010). "A Bayesian approach to genetic association studies with family-based designs". Genet. Epidemiol. 34 (6): 569–74. doi:10.1002/gepi.20513. PMC 3349938. PMID 20818722.
• Mittal S, Aslam A, Doidge R, Medica R, Winkler GS (March 2011). "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence". Mol. Biol. Cell. 22 (6): 748–58. doi:10.1091/mbc.E10-11-0898. PMC 3057700. PMID 21233283.
• Zhou W, Thiery JP (June 2013). "Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1". J. Cell. Sci. 126 (Pt 12): 2740–6. doi:10.1242/jcs.126367. PMID 23591815.
• Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C (February 2016). "Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation". Biochim. Biophys. Acta. 1863 (2): 263–70. doi:10.1016/j.bbamcr.2015.11.018. PMID 26608607.
• Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M (April 2016). "Structural basis for inhibition of the deadenylase activity of human CNOT6L". FEBS Lett. 590 (8): 1270–9. doi:10.1002/1873-3468.12160. PMID 27013054.
• Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N (April 2019). "Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis". Proc. Natl. Acad. Sci. U.S.A. 116 (16): 7973–7981. doi:10.1073/pnas.1816023116. PMC 6475422. PMID 30926667.