CLK1

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.[5][6]

CLK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK1, CLK, CLK/STY, STY, CDC like kinase 1
External IDsOMIM: 601951 MGI: 107403 HomoloGene: 101535 GeneCards: CLK1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.1Start200,853,009 bp[1]
End200,864,744 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1195

12747

Ensembl

ENSG00000013441

ENSMUSG00000026034

UniProt

P49759

P22518

RefSeq (mRNA)

NM_001024646
NM_001162407
NM_004071

NM_001042634
NM_009905

RefSeq (protein)

NP_001155879
NP_004062

NP_001036099

Location (UCSC)Chr 2: 200.85 – 200.86 MbChr 1: 58.41 – 58.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.[6]

Interactions

CLK1 has been shown to interact with ASF/SF2.[7][8]

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References

  1. GRCh38: Ensembl release 89: ENSG00000013441 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026034 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.
  6. "Entrez Gene: CLK1 CDC-like kinase 1".
  7. Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (Oct 1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. doi:10.1074/jbc.271.40.24569. PMID 8798720.
  8. Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.

Further reading


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