CLDN6

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene.[5][6][7] It belongs to the group of claudins.

CLDN6
Identifiers
Aliases	CLDN6, claudin 6
External IDs	OMIM: 615798 MGI: 1859284 HomoloGene: 10300 GeneCards: CLDN6
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,014,712 bp[1] End 3,020,071 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 23,679,249 bp[2] End 23,682,446 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • identical protein binding • GO:0001948 protein binding • virus receptor activity Cellular component • bicellular tight junction • cell junction • membrane • apicolateral plasma membrane • integral component of membrane • cell membrane Biological process • cell-cell junction organization • GO:0022415 viral process • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • viral entry Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9074	54419
Ensembl	ENSG00000184697	ENSMUSG00000023906
UniProt	P56747	Q9Z262
RefSeq (mRNA)	NM_021195	NM_018777
RefSeq (protein)	NP_067018	NP_061247
Location (UCSC)	Chr 16: 3.01 – 3.02 Mb	Chr 17: 23.68 – 23.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184697 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023906 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
6. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.
7. "Entrez Gene: CLDN6 claudin 6".

External links

• Human CLDN6 genome location and CLDN6 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Morita K, Sasaki H, Furuse M, Tsukita S (1999). "Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells". J. Cell Biol. 147 (1): 185–94. doi:10.1083/jcb.147.1.185. PMC 2164984. PMID 10508865.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Turksen K, Troy TC (2001). "Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium". Dev. Dyn. 222 (2): 292–300. doi:10.1002/dvdy.1174. PMID 11668606.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
• Turksen K, Troy TC (2002). "Permeability barrier dysfunction in transgenic mice overexpressing claudin 6". Development. 129 (7): 1775–84. PMID 11923212.
• Morita K, Furuse M, Yoshida Y, et al. (2002). "Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis". J. Invest. Dermatol. 118 (6): 1073–9. doi:10.1046/j.1523-1747.2002.01774.x. PMID 12060405.
• Reyes JL, Lamas M, Martin D, et al. (2003). "The renal segmental distribution of claudins changes with development". Kidney Int. 62 (2): 476–87. doi:10.1046/j.1523-1755.2002.00479.x. PMID 12110008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.