CLDN22

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene.[5] It belongs to the group of claudins.

CLDN22
Identifiers
Aliases	CLDN22, CLDN21, claudin 22
External IDs	MGI: 1922927 HomoloGene: 129823 GeneCards: CLDN22
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 183,318,194 bp[1] End 183,320,774 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.1 Start 47,824,482 bp[2] End 47,825,476 bp[2]
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • cell membrane • integral component of membrane • cell junction • membrane • bicellular tight junction Biological process • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53842	75677
Ensembl	ENSG00000177300	ENSMUSG00000038064
UniProt	Q8N7P3	Q9D7U6
RefSeq (mRNA)	NM_001111319	NM_029383
RefSeq (protein)	NP_001104789	NP_083659
Location (UCSC)	Chr 4: 183.32 – 183.32 Mb	Chr 8: 47.82 – 47.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000177300 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038064 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLDN22 claudin 22".

External links

• Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser.

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.