CLC (gene)

Eosinophil lysophospholipase is an enzyme that in humans is encoded by the CLC gene.[3][4]

CLC
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin
External IDsOMIM: 153310 HomoloGene: 130498 GeneCards: CLC
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start39,731,255 bp[1]
End39,738,029 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1178

n/a

Ensembl

ENSG00000105205

n/a

UniProt

Q05315

n/a

RefSeq (mRNA)

NM_001828

n/a

RefSeq (protein)

NP_001819

n/a

Location (UCSC)Chr 19: 39.73 – 39.74 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.[4]

See also

  • Charcot-Leyden crystals

References

  1. GRCh38: Ensembl release 89: ENSG00000105205 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
  4. "Entrez Gene: CLC Charcot-Leyden crystal protein".

Further reading


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