CLASP2

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.[5]

CLASP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WOY
Identifiers
Aliases	CLASP2, cytoplasmic linker associated protein 2
External IDs	OMIM: 605853 MGI: 1923749 HomoloGene: 24944 GeneCards: CLASP2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.3 Start 33,496,245 bp[1] End 33,718,356 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 113,741,473 bp[2] End 113,919,682 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine kinase binding • dystroglycan binding • microtubule binding • microtubule plus-end binding • actin filament binding • GO:0001948 protein binding • kinetochore binding Cellular component • cytoplasm • condensed chromosome kinetochore • Golgi apparatus • cell projection • kinetochore microtubule • membrane • focal adhesion • cell membrane • axonal growth cone • spindle • microtubule organizing center • chromosome • ruffle membrane • trans-Golgi network • cell cortex • cell leading edge • cortical microtubule plus-end • cytoplasmic microtubule • mitotic spindle • basal cortex • microtubule • chromosome, centromeric region • cytoskeleton • kinetochore • cytosol Biological process • vesicle targeting • regulation of actin cytoskeleton organization • regulation of axon extension • Golgi organization • GO:0043148 mitotic spindle organization • regulation of epithelial to mesenchymal transition • positive regulation of epithelial cell migration • exit from mitosis • cell division • establishment or maintenance of cell polarity • positive regulation of extracellular matrix disassembly • positive regulation of basement membrane assembly involved in embryonic body morphogenesis • negative regulation of microtubule depolymerization • microtubule anchoring • regulation of microtubule-based process • regulation of microtubule polymerization • regulation of microtubule polymerization or depolymerization • negative regulation of wound healing, spreading of epidermal cells • cell cycle • positive regulation of exocytosis • negative regulation of stress fiber assembly • microtubule organizing center organization • negative regulation of focal adhesion assembly • regulation of gastrulation • microtubule cytoskeleton organization • microtubule nucleation • platelet-derived growth factor receptor-beta signaling pathway • sister chromatid cohesion • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23122	76499
Ensembl	ENSG00000163539	ENSMUSG00000033392
UniProt	O75122	Q8BRT1
RefSeq (mRNA)	NM_001207044 NM_015097 NM_001365627 NM_001365628 NM_001365629 NM_001365630 NM_001365631 NM_001365632 NM_001365633 NM_001365634 NM_001375694 NM_001375697 NM_001375700 NM_001375701 NM_001375703 NM_001375705 NM_001375713 NM_001375715 NM_001375716 NM_001375718 NM_001375720	NM_001081960 NM_001114347 NM_001286599 NM_001286600 NM_001286601 NM_001286602 NM_001286603 NM_029633
RefSeq (protein)	NP_001193973 NP_055912 NP_001352556 NP_001352557 NP_001352558 NP_001352559 NP_001352560 NP_001352561 NP_001352562 NP_001352563 NP_001362623 NP_001362626 NP_001362629 NP_001362630 NP_001362632 NP_001362634 NP_001362642 NP_001362644 NP_001362645 NP_001362647 NP_001362649	NP_001075429 NP_001107819 NP_001273528 NP_001273529 NP_001273530 NP_001273531 NP_001273532 NP_083909
Location (UCSC)	Chr 3: 33.5 – 33.72 Mb	Chr 9: 113.74 – 113.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163539 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033392 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

External links

• Human CLASP2 genome location and CLASP2 gene details page in the UCSC Genome Browser.

Further reading

• Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
• Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. hdl:10216/53832. PMID 12837247.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance". Neuron. 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
• Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869.
• Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function" (PDF). Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.