CITED2

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.[5][6][7]

CITED2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P4Q, 1R8U
Identifiers
Aliases	CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
External IDs	OMIM: 602937 MGI: 1306784 HomoloGene: 4433 GeneCards: CITED2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.1 Start 139,371,807 bp[1] End 139,374,648 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A2 Start 17,723,218 bp[2] End 17,725,674 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • LBD domain binding • GO:0001948 protein binding • histone acetyltransferase binding • protein domain specific binding Cellular component • cytoplasm • nuclear chromatin • cell nucleus • nucleoplasm • macromolecular complex Biological process • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • adrenal cortex formation • positive regulation of transforming growth factor beta receptor signaling pathway • cell differentiation • response to hypoxia • regulation of transcription, DNA-templated • positive regulation of cell-cell adhesion • embryonic heart tube left/right pattern formation • ventricular septum morphogenesis • outflow tract morphogenesis • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • spleen development • negative regulation of gene expression • transcription, DNA-templated • response to fluid shear stress • response to estrogen • positive regulation of transcription, DNA-templated • multicellular organism development • heart development • determination of left/right symmetry • positive regulation of gene expression • negative regulation of cell migration • positive regulation of cell cycle • regulation of animal organ formation • sex determination • positive regulation of peroxisome proliferator activated receptor signaling pathway • liver development • left/right pattern formation • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia • cellular proliferation • negative regulation of transcription, DNA-templated • left/right axis specification • positive regulation of male gonad development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • positive regulation of nucleic acid-templated transcription • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10370	17684
Ensembl	ENSG00000164442	ENSMUSG00000039910
UniProt	Q99967	O35740
RefSeq (mRNA)	NM_006079 NM_001168388 NM_001168389	NM_010828
RefSeq (protein)	NP_001161860 NP_001161861 NP_006070	NP_034958
Location (UCSC)	Chr 6: 139.37 – 139.37 Mb	Chr 10: 17.72 – 17.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CITED2 has been shown to interact with EP300,[8][9][10][11] LHX2,[11] TFAP2A,[9][10] and WT1.[12]

References

1. GRCh38: Ensembl release 89: ENSG00000164442 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039910 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shioda T, Fenner MH, Isselbacher KJ (Oct 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
6. Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Nov 1999). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics. 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.
7. "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2".
8. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
9. Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
10. Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
11. Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
12. Val P, Martinez-Barbera JP, Swain A (Jun 2007). "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage". Development. 134 (12): 2349–58. doi:10.1242/dev.004390. PMID 17537799.

Further reading

• Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (Feb 2007). "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor". The Journal of Endocrinology. 192 (2): 459–65. doi:10.1677/JOE-06-0083. PMID 17283246.
• Shioda T, Fenner MH, Isselbacher KJ (Dec 1997). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
• Sun HB, Zhu YX, Yin T, Sledge G, Yang YC (Nov 1998). "MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity". Proceedings of the National Academy of Sciences of the United States of America. 95 (23): 13555–60. doi:10.1073/pnas.95.23.13555. PMC 24857. PMID 9811838.
• Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
• Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
• Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
• Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
• Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cellular & Developmental Biology. Animal. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
• Yokota H, Goldring MB, Sun HB (Nov 2003). "CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear". The Journal of Biological Chemistry. 278 (47): 47275–80. doi:10.1074/jbc.M304652200. PMID 12960175.
• Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S (Dec 2003). "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene". The EMBO Journal. 22 (23): 6299–309. doi:10.1093/emboj/cdg595. PMC 291836. PMID 14633989.
• Tien ES, Davis JW, Vanden Heuvel JP (Jun 2004). "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator". The Journal of Biological Chemistry. 279 (23): 24053–63. doi:10.1074/jbc.M401489200. PMID 15051727.
• Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S (Dec 2005). "Identification and functional analysis of CITED2 mutations in patients with congenital heart defects". Human Mutation. 26 (6): 575–82. doi:10.1002/humu.20262. PMID 16287139.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Chou YT, Yang YC (Jul 2006). "Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region". The Journal of Biological Chemistry. 281 (27): 18451–62. doi:10.1074/jbc.M601720200. PMID 16675452.
• Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC (Oct 2007). "Cited2, a coactivator of HNF4alpha, is essential for liver development". The EMBO Journal. 26 (21): 4445–56. doi:10.1038/sj.emboj.7601883. PMC 2063472. PMID 17932483.

External links

• CITED2 human gene location in the UCSC Genome Browser.
• CITED2 human gene details in the UCSC Genome Browser.