CITED1

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.[5][6][7]

CITED1
Identifiers
Aliases	CITED1, MSG1, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
External IDs	OMIM: 300149 MGI: 108023 HomoloGene: 3057 GeneCards: CITED1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 72,301,638 bp[1] End 72,307,187 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X D|X 45.25 cM Start 102,247,381 bp[2] End 102,252,181 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • co-SMAD binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • LBD domain binding • protein C-terminus binding • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • cell nucleus • nucleoplasm Biological process • negative regulation of neuron apoptotic process • response to transforming growth factor beta • positive regulation of transforming growth factor beta receptor signaling pathway • cell differentiation • response to cytokine • melanin biosynthetic process • spongiotrophoblast layer development • response to interleukin-1 • regulation of transcription, DNA-templated • SMAD protein signal transduction • response to interleukin-4 • response to interferon-gamma • response to interleukin-6 • placentation • regulation of transcription from RNA polymerase II promoter • response to interleukin-2 • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • labyrinthine layer development • response to interleukin-11 • negative regulation of Wnt signaling pathway • embryonic axis specification • negative regulation of osteoblast differentiation • transcription, DNA-templated • response to estrogen • vasculogenesis • positive regulation of transcription, DNA-templated • response to insulin • multicellular organism development • response to lipopolysaccharide • branching involved in ureteric bud morphogenesis • brain development • positive regulation of gene expression • response to parathyroid hormone • nucleocytoplasmic transport • pigmentation • response to cAMP • cellular proliferation • metanephros development • melanocyte differentiation • negative regulation of transcription, DNA-templated • response to interleukin-9 • transforming growth factor beta receptor signaling pathway • mesenchymal to epithelial transition • apoptotic process • positive regulation of transcription from RNA polymerase II promoter • regulation of apoptotic process • transcription from RNA polymerase II promoter • positive regulation of mesenchymal stem cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4435	12705
Ensembl	ENSG00000125931	ENSMUSG00000051159
UniProt	Q99966	P97769
RefSeq (mRNA)	NM_001144885 NM_001144886 NM_001144887 NM_004143	NM_001276466 NM_001276473 NM_001276474 NM_007709
RefSeq (protein)	NP_001138357 NP_001138358 NP_001138359 NP_004134	NP_001263395 NP_001263402 NP_001263403 NP_031735
Location (UCSC)	Chr X: 72.3 – 72.31 Mb	Chr X: 102.25 – 102.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CITED1 has been shown to interact with HSPA8[8] and EP300.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000125931 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051159 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
6. Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
7. "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
8. Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. UNITED STATES. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

External links

• Human CITED1 genome location and CITED1 gene details page in the UCSC Genome Browser.

Further reading

• Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
• Li H, Ahmed NU, Fenner MH, et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
• Shioda T, Lechleider RJ, Dunwoodie SL, et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. Bibcode:1998PNAS...95.9785S. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553.
• Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand). 45 (7): 1075–82. PMID 10644012.
• Yahata T, de Caestecker MP, Lechleider RJ, et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
• Ahmed NU, Shioda T, Coser KR, et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
• Yahata T, Shao W, Endoh H, et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164.
• Bragança J, Swingler T, Marques FI, et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shi G, Boyle SC, Sparrow DB, et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
• Lovvorn HN, Westrup J, Opperman S, et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia. 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162.