CHSY1

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.[5][6]

CHSY1
Identifiers
Aliases	CHSY1, CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDs	OMIM: 608183 MGI: 2681120 HomoloGene: 8950 GeneCards: CHSY1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 101,175,727 bp[1] End 101,252,048 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 66,109,515 bp[2] End 66,173,798 bp[2]
Gene ontology Molecular function • metal ion binding • transferase activity • acetylgalactosaminyltransferase activity • transferase activity, transferring glycosyl groups • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Cellular component • extracellular region • integral component of membrane • Golgi apparatus • Golgi membrane • Golgi cisterna membrane • membrane Biological process • proximal/distal pattern formation • bone morphogenesis • cartilage development • chondrocyte development • negative regulation of ossification • sulfation • positive regulation of smoothened signaling pathway • response to nutrient levels • chondroitin sulfate biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22856	269941
Ensembl	ENSG00000131873	ENSMUSG00000032640
UniProt	Q86X52	Q6ZQ11
RefSeq (mRNA)	NM_014918	NM_001081163
RefSeq (protein)	NP_055733	NP_001074632
Location (UCSC)	Chr 15: 101.18 – 101.25 Mb	Chr 7: 66.11 – 66.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.[7][6]

References

1. GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
6. "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
7. supplied by OMIM

External links

• Human CHSY1 genome location and CHSY1 gene details page in the UCSC Genome Browser.

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi:10.1074/jbc.M304421200. PMID 12907687.
• Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.